Luvadaxistat Explained

Legal Status:	Investigational
Synonyms:	TAK-831
Unii:	76IC00YRVR
Pubchem:	71270546
Iupac Name:	6-[2-[4-(Trifluoromethyl)phenyl]ethyl]-1,2-dihydropyridazine-3,4-dione
C:	13
H:	11
F:	3
N:	2
O:	2

Luvadaxistat is an experimental drug that works as a D-amino acid oxidase inhibitor and is supposed to increase NMDA receptor functionality.^[1] It is developed to treat Friedrich ataxia^[2] and negative symptoms of schizophrenia.^{[3] [4] [5]}

Notes and References

1. O’Donnell . Patricio . Dong . Cheng . Murthy . Venkatesha . Asgharnejad . Mahnaz . Du . Xiaoming . Summerfelt . Ann . Lu . Hong . Xu . Lin . Wendland . Jens R. . Dunayevich . Eduardo . Buhl . Derek L. . Litman . Robert . Hetrick . William P. . Hong . L. Elliot . Rosen . Laura B. . The D-amino acid oxidase inhibitor luvadaxistat improves mismatch negativity in patients with schizophrenia in a randomized trial . Neuropsychopharmacology . June 2023 . 48 . 7 . 1052–1059 . 10.1038/s41386-023-01560-0 . 36928351 . 10018616 . en . 1740-634X.
2. Wang . Hao . Norton . Jonathan . Xu . Lin . DeMartinis . Nicholas . Sen . Rohini . Shah . Ankit . Farmer . Jennifer . Lynch . David . Results of a randomized double‐blind study evaluating luvadaxistat in adults with Friedreich ataxia . Annals of Clinical and Translational Neurology . June 2021 . 8 . 6 . 1343–1352 . 10.1002/acn3.51373. 34018342 . 8164851 .
3. Fradley . Rosa . Goetghebeur . Pascal . Miller . David . Burley . Russell . Almond . Sarah . Gruart i Massó . Agnès . Delgado García . José M. . Zhu . Bin . Howley . Eimear . Neill . Jo C. . Grayson . Ben . Gaskin . Philip . Carlton . Mark . Gray . Ian . Serrats . Jordi . Davies . Ceri H. . Luvadaxistat: A Novel Potent and Selective d-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia . Neurochemical Research . October 2023 . 48 . 10 . 3027–3041 . 10.1007/s11064-023-03956-2. 37289348 . 10471729 .
4. Veselinović . Tanja . Neuner . Irene . Progress and Pitfalls in Developing Agents to Treat Neurocognitive Deficits Associated with Schizophrenia . CNS Drugs . August 2022 . 36 . 8 . 819–858 . 10.1007/s40263-022-00935-z. 35831706 . 9345797 .
5. Kuo . Chien-Yi . Lin . Chieh-Hsin . Lane . Hsien-Yuan . Targeting d-Amino Acid Oxidase (DAAO) for the Treatment of Schizophrenia: Rationale and Current Status of Research . CNS Drugs . November 2022 . 36 . 11 . 1143–1153 . 10.1007/s40263-022-00959-5. 36194364 . 252694226 .