Lutetium(III) chloride explained

Lutetium(III) chloride or lutetium trichloride is the chemical compound composed of lutetium and chlorine with the formula LuCl3. It forms hygroscopic white monoclinic crystals and also a hygroscopic hexahydrate LuCl3·6H2O.[1] Anhydrous lutetium(III) chloride has the YCl3 (AlCl3) layer structure with octahedral lutetium ions.[2]

Lutetium-177, a radioisotope that can be derived from Lutetium(III) chloride, is used in targeted cancer therapies.[3] When Lutetium-177 is attached to molecules that specifically target cancer cells, it can deliver localized radiation to destroy those cells while sparing surrounding healthy tissue.[4] This makes Lutetium-177-based treatments especially valuable for cancers that are difficult to treat with traditional methods, such as neuroendocrine tumors and prostate cancer.[5] Additionally, Lutetium(III) chloride is used in [scintillator]]s, materials that emit light when exposed to radiation.[6] These scintillators are crucial in detectors for gamma rays and other high-energy particles, used in both medical diagnostics and in scientific research.[7]

Reactions

Pure lutetium metal can be produced from lutetium(III) chloride by heating it together with elemental calcium:

2 LuCl3 + 3 Ca → 2 Lu + 3 CaCl2

See also

Notes and References

  1. Web site: Lutetium(III) chloride hexahydrate 542075. Sigma-Aldrich. 2019-07-24.
  2. Wells A.F. (1984) Structural Inorganic Chemistry 5th edition Oxford Science Publications
  3. Sgouros . George . Bodei . Lisa . McDevitt . Michael R. . Nedrow . Jessie R. . September 2020 . Radiopharmaceutical therapy in cancer: clinical advances and challenges . Nature Reviews Drug Discovery . en . 19 . 9 . 589–608 . 10.1038/s41573-020-0073-9 . 1474-1784.
  4. Vyas . Madhusudan . 2021-05-01 . Lutetium-177: a flexible radionuclide therapeutic options . Journal of Nuclear Medicine . en . 62 . supplement 1 . 3039–3039 . 0161-5505.
  5. Dash . Ashutosh . Pillai . Maroor Raghavan Ambikalmajan . Knapp . Furn F. . 2015-06-01 . Production of 177Lu for Targeted Radionuclide Therapy: Available Options . Nuclear Medicine and Molecular Imaging . en . 49 . 2 . 85–107 . 10.1007/s13139-014-0315-z . 1869-3482 . 4463871 . 26085854.
  6. Vogel . W. V. . van der Marck . S. C. . Versleijen . M. W. J. . 2021-07-01 . Challenges and future options for the production of lutetium-177 . European Journal of Nuclear Medicine and Molecular Imaging . en . 48 . 8 . 2329–2335 . 10.1007/s00259-021-05392-2 . 1619-7089 . 8241800 . 33974091.
  7. Das . Tapas . Banerjee . Sharmila . 2016 . Theranostic Applications of Lutetium-177 in Radionuclide Therapy . Current Radiopharmaceuticals . 9 . 1 . 94–101 . 10.2174/1874471008666150313114644 . 1874-4729 . 25771364.

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