| Lusignan | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Coat of Arms of the House of Lusignan (Kings of Cyprus).svg |
| Arrondissement: | Poitiers |
| Canton: | Lusignan |
| Insee: | 86139 |
| Postal Code: | 86600 |
| Mayor: | Jean-Louis Ledeux[1] |
| Term: | 2020–2026 |
| Intercommunality: | CU Grand Poitiers |
| Coordinates: | 46.4356°N 0.1236°W |
| Elevation M: | 132 |
| Elevation Min M: | 99 |
| Elevation Max M: | 159 |
| Area Km2: | 37.82 |
Lusignan (pronounced as /fr/) is a commune in the Vienne department in the Nouvelle-Aquitaine region in western France.It lies 25 km southwest of Poitiers. The inhabitants are called Mélusins and Mélusines.
The town of Lusignan now has about 3,000 inhabitants. It is located on the road RN11 from Poitiers to La Rochelle. It is about 400 km from Paris. It belongs to the Poitiers arrondissement and the Lusignan canton.
Right north of the town flows the river Vonne, a tributary of the Clain.
See main article: Château de Lusignan. Between the 10th and 14th centuries, the history of the town fully overlaps with that of the House of Lusignan.
During the 16th century Lusignan is repeatedly involved in the French Wars of Religion between Huguenots and Catholics.
The city walls were dismantled by royal orders in the 17th century.