| Official Name: | Lupiñén-Ortilla |
| Pushpin Map: | Spain#Spain Aragon |
| Pushpin Map Caption: | Location in Spain. |
| Subdivision Name3: | Hoya de Huesca |
| Leader Title: | Mayor |
| Leader Name: | Joaquín Mariano Til Aín |
| Area Total Km2: | 110.1 |
| Elevation M: | 469 |
| Population Demonym: | Lupiñenenses |
| Population Density Km2: | auto |
| Utc Offset: | +1 |
| Utc Offset Dst: | +2 |
| Coordinates: | 42.1761°N -0.5811°W |
Lupiñén-Ortilla is a municipality located in the province of Huesca, Aragon, Spain.