Lumirubin Explained

Lumirubin is a structural isomer of bilirubin, which is formed during phototherapy used to treat neonatal jaundice. This polar isomer resulting from the blue-green lights of phototherapy has an active site to albumin, and its effects are considered less toxic than those of bilirubin.[1] [2] [3] Lumirubin is excreted into bile or urine. ZZ, ZE, EE and EZ are the four structural isomers of bilirubin. ZZ is the stable, more insoluble form. Other forms are relatively soluble and are known as lumirubins. Phototherapy converts the ZZ form into lumirubins. Monoglucuronylated lumirubins are easily excreted.[4]

Notes and References

  1. Dvořák . Aleš . Pospíšilová . Kateřina . Žížalová . Kateřina . Capková . Nikola . Muchová . Lucie . Vecka . Marek . Vrzáčková . Nikola . Křížová . Jana . Zelenka . Jaroslav . Vítek . Libor . 2021 . The Effects of Bilirubin and Lumirubin on Metabolic and Oxidative Stress Markers . Frontiers in Pharmacology . 12 . 567001 . 10.3389/fphar.2021.567001 . 1663-9812 . 7969661 . 33746746. free .
  2. Jašprová . Jana . Dvořák . Aleš . Vecka . Marek . Leníček . Martin . Lacina . Ondřej . Valášková . Petra . Zapadlo . Miloš . Plavka . Richard . Klán . Petr . Vítek . Libor . 2020-03-10 . A novel accurate LC-MS/MS method for quantitative determination of Z-lumirubin . Scientific Reports . en . 10 . 1 . 4411 . 10.1038/s41598-020-61280-z . 32157102 . 7064611 . 2020NatSR..10.4411J . 212641930 . 2045-2322.
  3. Jasprova . Jana . Matteo Dal Ben . Eleonora Vianello . Iryna Goncharova . Marie Urbanova . Karolina Vyroubalova . Silvia Gazzin . Claudio Tiribelli . Martin Sticha . Marcela Cerna . Libor Vitek . 1 February 2016 . The Biological Effects of Bilirubin Photoisomers . PLOS ONE . 11 . 2 . e0148126 . 10.1371/journal.pone.0148126 . 26829016 . 4735493 . 2016PLoSO..1148126J . free.
  4. Ennever JF, Sobel M, McDonagh AF, Speck WT . Phototherapy for neonatal jaundice: in vitro comparison of light sources . Pediatr. Res. . 18 . 7 . 667–70 . July 1984 . 6540860 . 10.1203/00006450-198407000-00021. free .

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