Lumicitabine Explained

Lumicitabine (ALS-8176) is an antiviral drug which was developed as a treatment for respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). It acts as an RNA polymerase inhibitor.^[1] While it showed promise in early clinical trials,^{[2] [3]} poor results in Phase IIb trials led to it being discontinued from development for treatment of RSV.^[4] Research continues to determine whether it may be useful for the treatment of diseases caused by other RNA viruses, and it has been found to show activity against Nipah virus.^[5]

See also

• Palivizumab
• Presatovir
• Ziresovir

Notes and References

1. Wang G, Deval J, Hong J, Dyatkina N, Prhavc M, Taylor J, Fung A, Jin Z, Stevens SK, Serebryany V, Liu J, Zhang Q, Tam Y, Chanda SM, Smith DB, Symons JA, Blatt LM, Beigelman L . Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection . Journal of Medicinal Chemistry . 58 . 4 . 1862–78 . February 2015 . 25667954 . 10.1021/jm5017279 .
2. Brendish NJ, Clark TW . Antiviral treatment of severe non-influenza respiratory virus infection . Current Opinion in Infectious Diseases . 30 . 6 . 573–578 . December 2017 . 29095723 . 10.1097/QCO.0000000000000410 . 2662061 .
3. Patel K, Kirkpatrick CM, Nieforth KA, Chanda S, Zhang Q, McClure M, Fry J, Symons JA, Blatt LM, Beigelman L, DeVincenzo JP, Huntjens DR, Smith PF . Respiratory syncytial virus-A dynamics and the effects of lumicitabine, a nucleoside viral replication inhibitor, in experimentally infected humans . The Journal of Antimicrobial Chemotherapy . 74 . 2 . 442–452 . February 2019 . 30376079 . 10.1093/jac/dky415 . free .
4. Web site: Johnson & Johnson takes $630M hit on RSV drug bought with Alios. . Taylor P . fiercebiotech.com . 18 October 2018 .
5. Lo MK, Amblard F, Flint M, Chatterjee P, Kasthuri M, Li C, Russell O, Verma K, Bassit L, Schinazi RF, Nichol ST, Spiropoulou CF . Potent in vitro activity of β-D-4'-chloromethyl-2'-deoxy-2'-fluorocytidine against Nipah virus . Antiviral Research . 175 . 104712 . January 2020 . 31935422 . 10.1016/j.antiviral.2020.104712 . 7054849 .