| Honorific-Prefix: | Don |
| Luis Muñoz de Guzmán | |
| Honorific-Suffix: | Caballero de Santiago |
| Order: | Royal Governor of Chile |
| Primeminister: | Manuel de Godoy |
| Predecessor: | Francisco Tadeo Diez de Medina |
| Successor: | Juan Rodríguez Ballesteros |
| Birth Date: | 1735 |
| Birth Place: | Seville, Spain |
| Death Place: | Santiago, Chile |
| Spouse: | María Luisa Esterripa |
Luis Muñoz de Guzmán (1735 – 11 February 1808) was a Spanish colonial administrator who served as Royal Governor of Quito and Royal Governor of Chile.
. Leopoldo Castedo . Resumen de la Historia de Chile de Francisco Antonio Encina . 2 . 1954 . Empresa Editora Zig-Zag . Santiago, Chile . Spanish .
. Francisco Antonio Encina . Historia de Chile: desde la prehistoria hasta 1891 . I-XX . 1940–1952 . Editorial Nascimento . Santiago, Chile . Spanish .
. José Toribio Medina . Diccionario Biográfico Colonial de Chile . 1906 . Imprenta Elzeviriana . Santiago, Chile . Spanish . 562 .