| Luis López de Mesa | |
| Office: | Minister of Foreign Affairs |
| Term Start: | April 23, 1947 |
| Term End: | May 5, 1947 |
| President: | Mariano Ospina Pérez |
| Predecessor: | Carlos Lozano y Lozano |
| Term Start2: | August 12, 1938 |
| Term End2: | August 7, 1942 |
| President2: | Eduardo Santos Montejo |
| Predecessor2: | Francisco Samper Madrid |
| Successor2: | Gabriel Turbay Abunader |
| Office3: | Minister of National Education |
| Term Start3: | August 13, 1934 |
| Term End3: | September 24, 1935 |
| President3: | Alfonso López Pumarejo |
| Predecessor3: | Carlos Lozano y Lozano |
| Successor3: | Calixto Torres Umaña |
| Birth Name: | Luis Eduardo López de Mesa Gómez |
| Birth Date: | 12 October 1884 |
| Birth Place: | Don Matías, Antioquia, Colombia |
| Death Place: | Bogotá, D.C., Colombia |
| Nationality: | Colombian |
| Alma Mater: | National University of Colombia (MD) |
| Profession: | Medical Doctor |
Luis Eduardo López de Mesa Gómez (October12, 1884October18, 1967) was a Colombian medical doctor, Harvard psychiatrist, Dean of the National University of Colombia, Minister of National Education, and Minister of Foreign Affairs.