| Luis Ernesto Castro | |
| Fullname: | Luis Ernesto Castro Sánchez |
| Birth Date: | 31 July 1921 |
| Birth Place: | Montevideo, Uruguay |
| Position: | Forward |
| Years1: | 1936–1950 |
| Clubs1: | Nacional |
| Caps1: | 274 |
| Goals1: | 166 |
| Nationalyears1: | 1942–1954 |
| Nationalteam1: | Uruguay |
| Nationalcaps1: | 19 |
| Nationalgoals1: | 4 |
Luis Ernesto Castro Sánchez (31 July 1921 - 17 December 2002),[1] nicknamed Mandrake,[2] was a Uruguayan football forward who played for Uruguay in the 1954 FIFA World Cup.[3] He also played for Club Nacional de Football.