| Luis Aquino | |
| Position: | Pitcher |
| Bats: | Right |
| Throws: | Right |
| Birth Date: | 19 May 1964 |
| Birth Place: | Santurce, Puerto Rico |
| Debutleague: | MLB |
| Debutdate: | August 8 |
| Debutyear: | 1986 |
| Debutteam: | Toronto Blue Jays |
| Debut2league: | NPB |
| Debut2date: | March 31 |
| Debut2year: | 1996 |
| Debut2team: | Kintetsu Buffaloes |
| Finalleague: | MLB |
| Finaldate: | September 12 |
| Finalyear: | 1995 |
| Finalteam: | San Francisco Giants |
| Final2league: | NPB |
| Final2date: | October 5 |
| Final2year: | 1996 |
| Final2team: | Kintetsu Buffaloes |
| Statleague: | MLB |
| Stat1label: | Win–loss record |
| Stat1value: | 31–32 |
| Stat2label: | Earned run average |
| Stat2value: | 3.68 |
| Stat3label: | Strikeouts |
| Stat3value: | 318 |
| Teams: | |
Luis Antonio Colón Aquino [ah-KEE-noh] (born May 19, 1964) is a Puerto Rican former middle relief pitcher in Major League Baseball who played for the Toronto Blue Jays (1986), Kansas City Royals (1988–1992), Florida Marlins (1993–1994), Montreal Expos (1995) and San Francisco Giants (1995).
Aquino signed with the Toronto Blue Jays as an amateur free agent in 1981 and made his major league debut with Toronto in 1986. He was later traded to the Kansas City Royals for Juan Beníquez. Aquino played most of his professional career with the Royals, but also had major league appearances for the Marlins, Expos and Giants.
In a nine-year career, Aquino posted a 31–32 record with five saves and an ERA of 3.68, lower than the league average over his career.
Aquino was a member of the inaugural Florida Marlins team that began play in 1993.