| Type: | Cardinal |
| Honorific Prefix: | His Eminence |
| Luigi Serafini | |
| Prefect Emeritus of the Congregation of the Council | |
| Church: | Roman Catholic Church |
| Appointed: | 31 July 1885 |
| Term End: | 19 June 1893 |
| Predecessor: | Lorenzo Nina |
| Successor: | Angelo di Pietro |
| Other Post: | Cardinal-Bishop of Sabina (1888–94) |
| Ordination: | 25 August 1853 |
| Consecration: | 17 July 1870 |
| Consecrated By: | Costantino Patrizi Naro |
| Cardinal: | 12 March 1877 |
| Created Cardinal By: | Pope Pius IX |
| Rank: | Cardinal-Priest (1877–88) Cardinal-Bishop (1888–94) |
| Birth Name: | Luigi Serafini |
| Birth Date: | 6 June 1808 |
| Birth Place: | Magliano Sabina, Papal States |
| Death Place: | Rome, Kingdom of Italy |
| Buried: | Campo Verano |
| Parents: | Giuseppe Serafini Anna Giorgi |
Luigi Serafini (6 June 1808 – 1 February 1894) was a Roman Catholic bishop and cardinal.
He was born in Magliano Sabina in 1808, and ordained a priest in 1853. In 1870, he was ordained Bishop of Viterbo. In 1877, he was elevated to cardinal. He resigned as bishop of Viterbo in 1880. In 1884, he was appointed Prefect of the Apostolic Signatura. The following year, he was appointed Prefect of the Sacred Congregation of the Council. He died in 1894, at the age of eighty-five.