| Birth Date: | 17 June 1951 |
| Birth Place: | Formigine, Italy |
| Death Place: | Bologna, Italy |
| Height: | 2.1m (06.9feet) |
| Weight: | 105kg (231lb) |
| Sport: | Basketball |
| Club: | Virtus Bologna |
| Show-Medals: | yes |
Luigi Serafini (17 June 1951 – 23 August 2020) was an Italian basketball player. He was part of the Italian teams that won a bronze medal at the 1971 European championships and finished fourth in 1977. He competed at the 1972 and 1976 Olympics and finished in fourth and fifth place, respectively.