| Type: | bishop |
| Luigi Natoli | |
| Bishop of Caltagirone, Archbishop of Messina | |
| Birth Date: | 15 June 1799 |
| Birth Place: | Patti, Sicily, Italy |
| Death Date: | 24 February 1875 |
| Death Place: | Messina |
| Nationality: | Italian |
| Religion: | Roman Catholic |
Luigi Natoli (15 June 1799 – 24 February 1875) was a Sicilian Roman Catholic priest. He was born in Patti, in north-eastern Sicily. He was ordained on 2 March 1822; was appointed bishop of the Caltagirone on 15 March 1858; and became archbishop of Messina on 22 February 1867. He died on 24 February 1875.