| Type: | Cardinal |
| Honorific-Prefix: | His Eminence |
| Luigi Caetani | |
| Cardinal-Priest of Santa Pudenziana Archbishop Emeritus of Capua | |
| Archdiocese: | Archdiocese of Capua |
| Term: | 17 March 1624 - 1 March 1627 |
| Predecessor: | Antonio Caetani (iuniore) |
| Successor: | Girolamo Costanzo |
| Consecration: | 12 June 1622 |
| Consecrated By: | Ludovico Ludovisi |
| Cardinal: | 19 January 1626 |
| Created Cardinal By: | Pope Urban VIII |
| Rank: | Cardinal-Priest |
| Birth Date: | July 1595 |
| Birth Place: | Piedimonte, Campania, Kingdom of Naples |
| Death Place: | Rome, Latium, Papal State |
| Buried: | Basilica of Santa Pudenziana |
| Resting Place Coordinates: | 41.8984°N 12.4956°W |
| Nationality: | Italian |
| Religion: | Roman Catholic |
| Education: | doctorate in law |
| Coat Of Arms: | Coat of arms cardinals Luigi & Antonio Caetani.svg |
| Cardinal Name: | Luigi Caetani |
| Dipstyle: | His Eminence |
| Offstyle: | Your Eminence |
| See: | Basilica of Santa Pudenziana |
Luigi Caetani (July 1595 - 15 April 1642) was an Italian Cardinal of the Roman Catholic Church.
Caetani was born in Piedimonte. Son of Filippo I Caetani, duke of Sermoneta, and Camilla Gaetani dell'Aquila d'Aragona, of the dukes of Traetto.[1] Descendant of the family of Pope Boniface VIII, great-grand-nephew of Cardinal Niccolò Caetani, grand-nephew of Cardinal Enrico Caetani and nephew of Cardinals Bonifazio Caetani and Antonio Caetani (seniore), he studied first in Ravenna, where his uncle Bonifazio was legate, and then in Rome, where he obtained a doctorate in law.
He served as Archbishop of Capua from 17 March 1624 until his resignation on 1 March 1627. He was ordained a bishop on 12 June 1622 and appointed the coadjutor archbishop of Capua on 14 November 1622. Caetani was elevated to cardinal on 19 January 1626 and installed as the cardinal-priest of S. Pudenziana on 9 February 1626.
Cardinal Caetani was consecrated to the episcopacy by Ludovico Ludovisi. Having himself consecrated Ulderico Carpegna, Caetani is in the episcopal lineage of Pope Francis and Pope Benedict XVI.