| Map: | Lualaba River DRC.svg |
| Mouth Location: | Lualaba River |
| Subdivision Type1: | Country |
| Subdivision Name1: | Democratic Republic of the Congo |
The Lufira River is a tributary of the Lualaba River in the Democratic Republic of the Congo (DRC).
The Lufira rises in the Shaba plateau south of Likasi.The river was dammed in 1926 at Mwadingusha near Likasi to form Lake Tshangalele, a reservoir for a hydroelectric generator supplying power for copper smelting.It flows northwards through the Bia Mountains for about, joining the Lualaba in Lake Kisale.