Ludwig Cancer Research Explained

Ludwig Cancer Research
Founded Date:1971
Founder:Daniel K. Ludwig
Headquarters:New York, NY, USA
Zürich, Switzerland (European Office)
Key People:Chi Van Dang, MD,PhD, CEO and Scientific Director; Jonathan Skipper, PhD, President
Area Served:International
Focus:Cancer Research
Website:www.ludwigcancerresearch.org

Ludwig Cancer Research is an international community of scientists focused on cancer research, with the goal of preventing and controlling cancer.[1] It encompasses the Ludwig Institute for Cancer Research, an international non-profit organization founded in 1971 by philanthropist Daniel K. Ludwig. The Institute is headquartered in New York City, with a European office located in Zürich. There are currently three Ludwig Branches: Ludwig Lausanne, Ludwig Oxford and Ludwig Princeton. In addition, there are six Ludwig Centers at leading institutions across the United States of America. Together, the Institute, Branches and Centers are known as Ludwig Cancer Research.

Since its founding in 1971, Ludwig Cancer Research has committed more than US$2.5 billion to cancer research. Ludwig Cancer Research focuses on both basic research and translational research, with specific emphasis on cell biology, genomics, immunology, neuroscience, prevention, cell signaling, stem cells, therapeutics, and tumor biology, as well as clinical trials and the design and development of small molecules with drug-like properties.[2] Its researchers also focus on particular types of malignancy, including brain cancer, breast cancer, colon cancer, and melanoma.[3]

Founder and history

Daniel K. Ludwig was a shipping magnate and real estate investor. Born in South Haven, Michigan in 1897, he used a $5,000 loan from his father to create a global business based on a fleet of supertankers.[4] In the 1960s and 1970s, Ludwig was among the richest men in the world, owning approximately 200 companies.[5]

He founded the Ludwig Institute for Cancer Research as an independent organization in 1971, the same year that the “War on Cancer,” declared by his friend President Richard Nixon, led to the establishment of the US National Cancer Institute.[6] Ludwig believed that tackling the problem of cancer required the best minds operating in the most favorable conditions with the best resources to accomplish the task. This principle continues to guide Ludwig Cancer Research.[7]

Daniel K. Ludwig endowed the Institute with all of the foreign assets from his business holdings. Upon his death in 1992, that endowment had grown to more than $700 million, and, as of 2012, it stands at more than $1.2 billion.

After Ludwig's death, his US-based assets were also put into a trust to support additional cancer research efforts. These funds led to the establishment of Ludwig Centers at six research institutions in 2006.[8] The Ludwig Institute for Cancer Research and Ludwig Centers have been known collectively as Ludwig Cancer Research since 2012.[9] In total, Ludwig Cancer Research has committed more than US$2.5 billion to cancer research worldwide since 1971.[10]

Mission and goals

The primary objectives of Ludwig Cancer Research are to prevent and control cancer through basic and translational research.

Research

Immunotherapy

Lloyd J. Old, the organization's former director, and scientific chairman, participated in the discovery of Tumor Necrosis Factor (TNF)[11] and the tumor suppressor p53.[12] He contributed to the immunosurveillance hypothesis, from which modern cancer immunotherapy can be derived.

Thierry Boon, former director of the organization's Brussels branch, made foundational contributions to the field of cancer immunotherapy. The prevailing model of carcinogenesis in the late 1970s held that spontaneously arising tumors were unlikely to elicit immune responses. Boon and his team, who believed otherwise, were the first to isolate genes that code for a family of tumor antigens and show that T cells could recognize and target cancer cells bearing such antigens.[13] This theory is being tested in a number of current clinical trials.[14]

Ludwig researchers in Melbourne discovered and cloned[15] the granulocyte-monocyte colony-stimulating factor (GM-CSF) through a collaboration with Australian immunologist Donald Metcalf. The factor is essential to the maturation of key white blood cells, and has been used extensively over the past few decades to help rebuild the immune system of patients undergoing chemotherapy. It is also being tested as a therapeutic agent in combination with several experimental immunotherapies for cancer. The Oncology Drug Advisory Committee of the US FDA recently recommended approval for T-VEC, a viral therapy for melanoma manufactured by Amgen that incorporates the gene for GM-CSF to support anti-cancer immune responses.[16]

Ludwig researchers in São Paulo played a role in establishing that human papillomavirus (HPV) infection causes cervical cancer. They ran the largest epidemiological studies of HPV infection and reported that chronic, though not transient, infection by the virus dramatically increases the risk of cervical cancer, laying the groundwork for the clinical development of an HPV vaccine.[17]

Current and former Ludwig researchers contributed to an emerging class of cancer immunotherapies known as checkpoint inhibitors. They explored the underlying immunology of the response and played a role in evaluating the first such drug in clinical trials for the treatment of advanced melanoma.[18] This led the development of new criteria for evaluating responses of cancer patients to immunotherapy in clinical trials.[19]

Cell signaling

Identification of signaling pathways and subsequent development of therapeutics are examples of contributions to the field of cell signaling. The PI3K family of proteins, for example, play an important role in cell signaling that feeds cancer.[20] This research resulted in the first Ludwig spin-off, Piramed Ltd., a biotech that sought to create cancer medicines based on this discovery. The pharmaceutical company Roche purchased the company. Drugs based on these discoveries are now being evaluated for the treatment of many cancers, including breast and lung cancer.

Genomics

Contributions in the field of genomics include the work of Ludwig researchers at Johns Hopkins to sequence the full complement of genes expressed in many cancers, including head and neck, colon, and breast cancers, as well as glioblastoma multiforme (GBM). Ludwig researchers in San Diego significantly advanced studies of the epigenome, leading such efforts as the NIH's Roadmap Epigenomics Project.[21]

Leadership

The Ludwig Cancer Research board of directors helps oversee both the Ludwig Institute for Cancer Research and the Ludwig Fund. Although each of these entities has its own board, the boards comprise the same individuals.[22] The current chairman of the board is Edward McDermott, Jr., former President and CEO of LICR.

The executive staff manages the organization's worldwide efforts.

It was announced in December 2016 that Chi Van Dang would take over the role of Scientific Director in July 2017.[23] He is responsible for coordinating the organization's global research efforts and activities.

Notable faculty

Notable awards received by past and present employees affiliated with Ludwig include:

Nobel Prize

National Medal of Science (US):

Fellows of the National Academy of Sciences (US):[29]

Academy of Medical Sciences (UK):[37]

Locations

Branches and laboratories[40]

Ludwig Centers

Notes and References

  1. Web site: About . live . https://web.archive.org/web/20150731065059/https://www.ludwigcancerresearch.org/about/ . 31 July 2015 . 4 August 2015 . Ludwig Cancer Research.
  2. News: Weintraub. Karen. Six cancer centers to share $540 million research gift. 4 August 2015. USA Today. 6 January 2014. 13 June 2016. https://web.archive.org/web/20160613050454/http://www.usatoday.com/story/news/nation/2014/01/06/540-million-gift-cancer-research/4303471/. live.
  3. Web site: Collaborative Areas. Ludwig Cancer Research. 4 August 2015. 16 September 2015. https://web.archive.org/web/20150916221059/http://www.ludwigcancerresearch.org/our-science/research-areas/collaborative-areas. live.
  4. News: Pace. Eric. Daniel Ludwig, Billionaire Businessman, Dies at 95. 4 August 2015. New York Times. 29 August 1002. 13 July 2015. https://web.archive.org/web/20150713192432/http://www.nytimes.com/1992/08/29/us/daniel-ludwig-billionaire-businessman-dies-at-95.html. live.
  5. News: Valdmanis. Richard. 2014-01-06. Billionaire Ludwig's estate donates $540 million for U.S. cancer research. en. Reuters. 2021-06-15. 2021-07-17. https://web.archive.org/web/20210717203859/https://www.reuters.com/article/us-usa-cancer-ludwig-idUSBREA0504Y20140106. live.
  6. News: Marshall. Eliot. A Billionaire's Final Gift to Six US Cancer Centers. 4 August 2015. Science. 6 January 2014. 9 January 2014. https://web.archive.org/web/20140109085857/http://news.sciencemag.org/funding/2014/01/billionaires-final-gift-six-u.s.-cancer-centers. live.
  7. News: Lane. Sir David. Trusting in Talent: How Daniel K. Ludwig's formula for success has fuelled four decades -- and counting -- of top-notch cancer research. 4 August 2015. Oncology News. August 2014. 24 March 2016. https://web.archive.org/web/20160324171821/https://issuu.com/oncologynews/docs/010714/18. live.
  8. News: Notter. John. Scientific Leaps Require Donors to Give Bigger. 4 August 2015. Chronicle of Philanthropy. 10 April 2014.
  9. Web site: New Paths of Discovery: 2012 Research Highlights. Ludwig Cancer Research. 4 August 2015. 28 October 2015. https://web.archive.org/web/20151028164731/http://www.ludwigcancerresearch.org/sites/default/files/media/news-pdf/Ludwig_Annual_2012.pdf. dead.
  10. News: Lane. Sir David. Fighting Cancer With Smart Funding. 4 August 2015. Huffington Post. 24 March 2014. 25 September 2015. https://web.archive.org/web/20150925010349/http://www.huffingtonpost.com/sir-david-lane-phd/fighting-cancer-with-smart-funding_b_5025002.html. live.
  11. Old. Lloyd J.. Purification and characterization of a human tumor necrosis factor from the LuKII cell line. Proceedings of the National Academy of Sciences. October 1985. 82. 19. 6637–6641. 10.1073/pnas.82.19.6637 . 3863119. etal. 391265. free.
  12. Old. Lloyd J.. Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proceedings of the National Academy of Sciences. May 1979. 76. 5. 2420–2424. 10.1073/pnas.76.5.2420 . 221923. etal. 383613. free.
  13. Coulie. Pierre G.. Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy. Nature Reviews Cancer. 24 January 2014. 14. 2. 135–146. 10.1038/nrc3670. etal. 24457417. 205469848.
  14. Web site: Search results for "MAGE". ClinicalTrials.gov. 12 August 2015. 4 March 2016. https://web.archive.org/web/20160304074007/https://clinicaltrials.gov/ct2/results?term=MAGE&Search=Search. live.
  15. Gough. N.M.. Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor.. The EMBO Journal. March 1985. 4. 3. 645–653. etal. 554237. 3874057. 10.1002/j.1460-2075.1985.tb03678.x.
  16. News: Davenport. Liam. Injectable T-VEC Offers Hope to Melanoma Patients. 12 August 2015. Medscape. 28 May 2015. 23 April 2016. https://web.archive.org/web/20160423035121/http://www.medscape.com/viewarticle/845504. live.
  17. Villa. L.L.. Overview of the clinical development and results of a quadrivalent HPV (types 6, 11, 16, 18) vaccine.. International Journal of Infectious Diseases. November 2007. S17–25. 10.1016/S1201-9712(07)60017-4. 18162241. 11. Suppl 2 . free.
  18. Hodi. F. Stephen. Improved Survival with Ipilimumab in Patients with Metastatic Melanoma. The New England Journal of Medicine. 19 August 2010. 363. 8. 711–723. 10.1056/NEJMoa1003466. etal. 20525992. 3549297.
  19. Wolchok. J.D.. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria.. Clinical Cancer Research. 1 December 2009. 15. 23. 7412–7420. 10.1158/1078-0432.CCR-09-1624. 19934295. etal. free.
  20. Katso . R. . etal . 2001 . Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. . Annual Review of Cell and Developmental Biology . 17 . 615–675 . 10.1146/annurev.cellbio.17.1.615 . 11687500.
  21. Vogelstein. Bert. Cancer Genome Landscapes. Science. 29 March 2013. 339. 6127. 1546–1558. 10.1126/science.1235122. etal. 23539594. 3749880.
  22. Web site: Leadership. Ludwig Cancer Research. 8 August 2015. 4 August 2015. https://web.archive.org/web/20150804184650/http://www.ludwigcancerresearch.org/our-people/leadership. live.
  23. Web site: Press Release. 5 February 2017. 6 February 2017. https://web.archive.org/web/20170206022227/http://www.ludwigcancerresearch.org/news/chi-van-dang-appointed-scientific-director-ludwig-institute-cancer-research. live.
  24. Web site: Peter Ratcliffe Nobel Prize facts . 18 April 2024 . www.nobelprize.org.
  25. Web site: Lucy Shapiro Lab . 16 April 2024 . Ludwig Cancer Research.
  26. Web site: The President's National Medal of Science: Recipient Details. National Science Foundation. 15 August 2015. 5 March 2016. https://web.archive.org/web/20160305131103/http://www.nsf.gov/od/nms/recip_details.jsp?recip_id=5300000000482. live.
  27. Web site: M.I.T. Center . 16 April 2024 . Ludwig Cancer Research.
  28. Web site: The President's National Medal of Science: Recipient Details. National Science Foundation. 15 August 2015. 5 March 2016. https://web.archive.org/web/20160305133327/http://www.nsf.gov/od/nms/recip_details.jsp?recip_id=379. live.
  29. Web site: Member Directory. National Academy of Sciences. 15 August 2015. 26 March 2017. https://web.archive.org/web/20170326120054/http://www.nasonline.org/member-directory/. live.
  30. Web site: Web Cavenee Lab . unfit . https://web.archive.org/web/20150806202253/http://www.ludwigcancerresearch.org/location/san-diego-branch/web-cavenee-lab . 6 August 2015 . 15 August 2015 . Ludwig Cancer Research.
  31. Web site: Don Cleveland Lab . unfit . https://web.archive.org/web/20181212203926/https://www.ludwigcancerresearch.org/location/san-diego-branch/don-cleveland-lab . 12 December 2018 . 15 August 2015 . Ludwig Cancer Research.
  32. Web site: Richard Kolodner Lab . unfit . https://web.archive.org/web/20151007023432/http://www.ludwigcancerresearch.org/location/san-diego-branch/richard-kolodner-lab . 7 October 2015 . 15 August 2015 . Ludwig Cancer Research.
  33. Web site: MSK Center . 16 April 2024 . Ludwig Cancer Research.
  34. Web site: Stanford Center . 16 April 2024 . Ludwig Cancer Research.
  35. Web site: Johns Hopkins Center . 16 April 2024 . Ludwig Cancer Research.
  36. Web site: Harvard Center . 16 April 2024 . Ludwig Cancer Research.
  37. Web site: Fellows Directory. The Academy of Medical Sciences. 15 August 2015. 10 August 2015. https://web.archive.org/web/20150810000607/http://www.acmedsci.ac.uk/fellows/fellows-directory/. live.
  38. Web site: Xin Lu Lab . 16 April 2024 . Ludwig Cancer Research Oxford.
  39. Web site: Peter Ratcliffe Lab . 16 April 2024 . Ludwig Cancer Research Oxford.
  40. Web site: Locations . 16 April 2024 . Ludwig Cancer Research.