Lucius Clodius Macer was a legatus of the Roman Empire in Africa during the reign of Nero. He revolted in May 68, cutting off the food supply of Rome, possibly at the instigation of Calvia Crispinilla. Although encouraged by Galba, Macer raised a legion Legio I Macriana liberatrix in addition to the Legio III Augusta that he already commanded, presumably raising suspicion that Macer also harbored imperial ambitions. In October 68, Galba had him killed by the procurator Trebonius Garutianus. Papirus, the centurion of Mucianus, was implicated in his assassination.
Macer produced denarii which are extremely rare today. Only about 85 have been found, of which only 20 bear his portrait. He uses the formulaic abbreviation S C (senatus consulto) on his denarii; this otherwise had only rarely appeared on Roman silver coins since about 40 BC. Scholars speculate that this, and his decision to portray himself without a laurel wreath or a diadem, as evidence that he portrayed his revolt as being against Nero, and not the senate.