| Lucio Marineo Siculo | |
| Birth Date: | 1444 or 1445 |
| Birth Place: | Vizzini, Kingdom of Sicily |
| Death Date: | 1533 (aged 88–89) |
| Death Place: | Kingdom of Spain |
| Nationality: | Sicilian |
| Occupation: | humanist, historian |
Lucio Marineo Siculo (Vizzini, 1444 or 1445 – Spain, 1533) was a Sicilian humanist, historian and poet, known as a prominent figure of the Spanish Renaissance.
He first taught Greek and Latin literature in Palermo. He moved to Spain and taught for twelve years at the University of Salamanca. His teaching and books influenced the development of the Spanish Renaissance, and his disciples included Alfono de Segura. King Ferdinand brought him to the royal court to serve as chaplain and chronicler. He was also charged with the education of the children of the nobility.