4-HO-MPMI explained

4-HO-MPMI (also known as 4-Hydroxy-N-methyl-(α,N-trimethylene)-tryptamine or lucigenol) is a tryptamine derivative that is a psychedelic drug. It was developed by the team led by David Nichols from Purdue University in the late 1990s. This compound produces hallucinogen-appropriate responding in animal tests with a similar potency to the amphetamine-derived psychedelic DOI, and has two enantiomers, with only the (R)-enantiomer being active.[1]

The binding affinity for 5-HT2A receptor is 13 ± 2 nM (Ki [125I]DOI). It is reported at doses starting at 0.5 mg and 1.0-1.5 mg seem to be psychedelic doses. The duration it is reported between six and eight hours. The effects, still not too documented, are OEV/CEV, sedation and anxiety.[2]

See also

Notes and References

  1. 10.1021/jm990325u . Gerasimov M, Marona-Lewicka D, Kurrasch-Orbaugh DM, Qandil AM, Nichols DE . Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain . Journal of Medicinal Chemistry . 1999 . 42 . 20 . 4257–4263 . 10514296. 10.1.1.690.4941 .
  2. Web site: Lucigenol Info - Hip Forums . 2010-08-02 . https://web.archive.org/web/20110711171020/http://www.hipforums.com/newforums/showthread.php?t=315326 . 2011-07-11 . dead .