| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Luca Semproni | |
| Bishop of Città di Castello | |
| Church: | Catholic Church |
| Diocese: | Diocese of Città di Castello |
| Term: | 1610–1616 |
| Predecessor: | Valeriano Muti |
| Successor: | Evangelista Tornioli |
| Consecration: | 9 May 1610 |
| Consecrated By: | Michelangelo Tonti |
| Birth Place: | Rimini, Italy |
| Death Date: | 15 Jan 1616 |
Luca Semproni (died 1616) was a Roman Catholic prelate who served as Bishop of Città di Castello (1610–1616).
Luca Semproni was born in Rimini, Italy.On 26 Apr 1610, Luca Semproni was appointed during the papacy of Pope Paul V as Bishop of Città di Castello.On 9 May 1610, he was consecrated bishop by Michelangelo Tonti, Bishop of Cesena, with Metello Bichi, Bishop Emeritus of Sovana, and Alessandro Borghi, Bishop Emeritus of Sansepolcro, serving as co-consecrators.He served as Bishop of Città di Castello until his death on 15 Jan 1616.
While bishop, he was the principal consecrator of Domenico de' Marini, Bishop of Albenga (1611).