| Luca Ruffini | |
| Birth Date: | 2 May 1997 |
| Birth Place: | Carpenedolo, Italy |
| Height: | 1.75 m |
| Currentclub: | Real Calepina |
| Clubnumber: | 24 |
| Position: | Left-back |
| Youthyears1: | 2013–2014 |
| Youthclubs1: | Parma |
| Years1: | 2014–2015 |
| Clubs1: | Parma |
| Caps1: | 0 |
| Goals1: | 0 |
| Years2: | 2014–2015 |
| Clubs2: | → Castiglione (loan) |
| Caps2: | 32 |
| Goals2: | 1 |
| Years3: | 2015–2016 |
| Clubs3: | Pro Piacenza |
| Caps3: | 28 |
| Goals3: | 1 |
| Years4: | 2016–2018 |
| Clubs4: | Feralpisalò |
| Caps4: | 13 |
| Goals4: | 0 |
| Years5: | 2017–2018 |
| Clubs5: | → Rezzato (loan) |
| Caps5: | 27 |
| Goals5: | 0 |
| Years6: | 2018–2020 |
| Clubs6: | AlbinoLeffe |
| Caps6: | 41 |
| Goals6: | 1 |
| Years7: | 2020–2022 |
| Clubs7: | Desenzano |
| Caps7: | 56 |
| Goals7: | 5 |
| Years8: | 2022–2023 |
| Clubs8: | Franciacorta |
| Caps8: | 19 |
| Goals8: | 0 |
| Years9: | 2023– |
| Clubs9: | Real Calepina |
| Caps9: | 17 |
| Goals9: | 2 |
| Club-Update: | 20 December 2023 |
Luca Ruffini (born 2 May 1997) is an Italian footballer who plays as a defender for Serie D club Real Calepina.