| Official Name: | Lubombo Region |
| Native Name: | eLubonjeni |
| Mapsize: | 200px |
| Subdivision Type: | Country |
| Seat Type: | Capital |
| Seat: | Siteki |
| Leader Title: | Regional Administrator |
| Leader Name: | Mr Esau Dube |
| Leader Title1: | Regional Secretary |
| Leader Name1: | Mr Eric Maziya |
| Area Total Km2: | 5849.11 |
| Population As Of: | 2017 census |
| Population Total: | 212,531[1] |
| Population Density Km2: | auto |
| Utc Offset: | +2 |
| Coordinates: | -26.4167°N 76°W |
| Blank Name Sec1: | HDI (2017) |
| Blank Info Sec1: | 0.596[2] |
Lubombo is a region of Eswatini, located in the east of the country. It has an area of 5,849.11 km2 and a population of 212,531 (2017). Its administrative center is Siteki. It borders all three other regions: Hhohho to the north, Manzini to the west, and Shiselweni to the south. It is divided into 11 tinkhundla.
Geographically, the region is dominated almost entirely by the Lubombo Mountains.The Lubombo District is the easternmost of the four regions of Eswatini. Its capital is Siteki.
Lubombo is subdivided to 11 tinkhundla (or constituencies). These are local administration centres, and also parliamentary constituencies. Each inkhundla is headed by an indvuna yenkhundla or governor with the help of bucopho. The tinkhundla are further divided into imiphakatsi (or chiefdoms). The present tinkhundla are: