Lu AA47070 explained
| Class: | Adenosine A2A receptor antagonist |
| Cas Number: | 913842-25-8 |
| Pubchem: | 11947802 |
| Chemspiderid: | 62804024 |
| Unii: | S4AD6SAU9U |
| Chembl: | 1671940 |
| Synonyms: | Lu-AA47070; LU AA 47070; LU-AA-47070 |
| Iupac Name: | [2-[4-(3,3-dimethylbutanoylamino)-3,5-difluorobenzoyl]imino-1,3-thiazol-3-yl]methyl dihydrogen phosphate |
| C: | 17 |
| H: | 20 |
| F: | 2 |
| N: | 3 |
| O: | 6 |
| P: | 1 |
| S: | 1 |
| Smiles: | CC(C)(C)CC(=O)NC1=C(C=C(C=C1F)C(=O)N=C2N(C=CS2)COP(=O)(O)O)F |
| Stdinchi: | 1S/C17H20F2N3O6PS/c1-17(2,3)8-13(23)20-14-11(18)6-10(7-12(14)19)15(24)21-16-22(4-5-30-16)9-28-29(25,26)27/h4-7H,8-9H2,1-3H3,(H,20,23)(H2,25,26,27) |
| Stdinchikey: | MSWIQSFUBYCFJE-UHFFFAOYSA-N |
Lu AA47070 is a selective adenosine A2A receptor antagonist that was under development for the treatment of Parkinson's disease but was never marketed.[1] [2] [3]
Notes and References
- Web site: LU AA 47070 . AdisInsight . Springer Nature Switzerland AG . 18 May 2009 . 22 September 2024.
- Sachdeva S, Gupta M . Adenosine and its receptors as therapeutic targets: An overview . Saudi Pharmaceutical Journal . 21 . 3 . 245–253 . July 2013 . 23960840 . 3744929 . 10.1016/j.jsps.2012.05.011 . Antagonists of the A2A subtype of adenosine receptor have emerged as a leading candidate class of nondopaminergic antiparkinsonian agents (Feigin, 2003). The ability of Lu AA47070, adenosine A2A antagonist to reverse the effects of D2 receptor blockade suggests that this compound could have potential utility as a treatment for parkinsonism, and for some of the motivational symptoms of depression. In the adult male Sprague Dawley rats the tremulous jaw movements induced by subchronic administration of the DA D2 antagonist pimozide were reversed by Lu AA47070. Lu AA47070 was also able to reverse the catalepsy induced by subchronic administration of the D2 antagonist pimozide and it also reverse the locomotor suppression induced by subchronic administration of the D2 antagonist pimozide (Collins et al., 2012). .
- Sams AG, Mikkelsen GK, Larsen M, Langgård M, Howells ME, Schrøder TJ, Brennum LT, Torup L, Jørgensen EB, Bundgaard C, Kreilgård M, Bang-Andersen B . 6 . Discovery of phosphoric acid mono- ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist | journal = Journal of Medicinal Chemistry | volume = 54 | issue = 3 | pages = 751–764 | date = February 2011 | pmid = 21210664 | doi = 10.1021/jm1008659 }.
