Tedatioxetine Explained

Tedatioxetine (developmental code name Lu AA24530) is an experimental antidepressant that was discovered by scientists at Lundbeck; in 2007 Lundbeck and Takeda entered into a partnership that included tedatioxetine but was focused on another, more advanced Lundbeck drug candidate, vortioxetine.^[1]

Tedatioxetine is reported to act as a triple reuptake inhibitor (serotonin > norepinephrine > dopamine) and 5-HT_2A, 5-HT_2C, 5-HT₃, and α_1A-adrenergic receptor antagonist.^{[2] [3] [4] [5]}

As of 2009, it was in phase II clinical trials for major depressive disorder, but there have been no updates since then, and as of August 2013 it was no longer displayed on Lundbeck's product pipeline.^{[6] [7]}

On May 10, 2016, all work on tedatioxetine stopped.^[8]

A Chinese patent shows that there has been interest in this compound outside of Lundbeck.^[9]

See also

• MIN-117
• TGBA01AD
• Vilazodone
• Vortioxetine

External links

• Lu AA24530 shows positive results in major depressive disorder phase II study

Notes and References

1. Web site: Beaulieu D . First Word Pharma . 5 September 2007 . Lundbeck, Takeda enter strategic alliance for mood disorder, anxiety drugs ].
2. US . 2010144788 . Stensbol TB, Miller S . 10 June 2010 . H Lundbeck AS . 4-[2-(4-methylphenylsulfanyd-phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of adhd, melancholia, treatment resistant depression or residual symptoms in depression .
3. Book: Stahl SM . Depression and bipolar disorder: Stahl's essential psychopharmacology . 22 November 2011 . 19 May 2008 . Cambridge University Press . 978-0-521-88663-5 . 206.
4. Book: Stolerman IP . Encyclopedia of Psychopharmacology . 22 November 2011 . 30 August 2010 . Springer . 978-3-540-68698-9 . 105.
5. Web site: Lu AA24530 shows positive results in major depressive disorder phase II study . FierceBiotech . 2 July 2009 .
6. Web site: Pipeline of Lundbeck . 25 August 2013 . 28 September 2012 . https://web.archive.org/web/20120928080247/http://investor.lundbeck.com/pipeline.cfm . dead .
7. Web site: UK Medicines Information . Tedatioxetine . 20 January 2016 .
8. Web site: Tedatioxetine . AdisInsight . Springer Nature Switzerland AG . 2016-06-09.
9. WO. 2015090160. Compound for preparing 4-(2-(4-methylphenylthio))phenylpiperidine, and preparation method and use thereof. 2015-06-25. NHWA Pharma Corp.. Cao . Longji. Xin . Jianchuang. Yang . Xiangping.