Lovastatin nonaketide synthase explained

lovastatin nonaketide synthase
Ec Number:	2.3.1.161
Cas Number:	235426-97-8
Go Code:	0050637

In enzymology, lovastatin nonaketide synthase is an enzyme that catalyzes the chemical reaction

acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 10 H⁺ + S-adenosyl-L-methionine

\rightleftharpoons dihydromonacolin L + 9 CoA + 8 CO₂ + 11 NADP⁺ + S-adenosyl-L-homocysteine + 6 H₂O

The 5 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, H⁺, and S-adenosyl-L-methionine, whereas its 6 products are dihydromonacolin L, CoA, CO₂, NADP⁺, S-adenosyl-L-homocysteine, and H₂O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing).

References

• Heever JP, Hutchinson CR, Vederas JC . 2000 . Lovastatin nonaketide synthase catalyses an intramolecular Diels-Alder reaction of a substrate analogue . J. Am. Chem. Soc. . 122 . 11519 - 11520 . 10.1021/ja003216 . 46 .