| Office: | Justice of the Supreme Court of Virginia |
| Term Start: | November 20, 1929 |
| Term End: | February 14, 1935 |
| Predecessor: | Jesse F. West |
| Successor: | John W. Eggleston |
| Office1: | Member of the Virginia State Corporation Commission |
| Term Start1: | November 16, 1925 |
| Term End1: | November 16, 1929 |
| Predecessor1: | William F. Rhea |
| Successor1: | George C. Peery |
| State Senate2: | Virginia |
| District2: | 9th |
| Term Start2: | January 9, 1924 |
| Term End2: | November 1925 |
| Preceded2: | F. Percy Loth |
| Succeeded2: | Edwin L. Kendig |
| State Senate3: | Virginia |
| District3: | 28th |
| Term Start3: | January 14, 1920 |
| Term End3: | January 9, 1924 |
| Preceded3: | George E. Allen |
| Succeeded3: | W. Worth Smith, Jr. |
| Birth Name: | Louis Spencer Epes |
| Birth Date: | 12 January 1882 |
| Birth Place: | Prince William, Virginia, U.S. |
| Death Place: | Richmond, Virginia, U.S. |
| Alma Mater: | Hampden-Sydney College Washington & Lee University |
| Spouse: | Julia Pegram Bagley |
Louis Spencer Epes (January 12, 1882 – February 14, 1935) was an American lawyer, judge and politician. He served as a member of the Senate of Virginia and was appointed as a justice of the Supreme Court of Virginia.
Epes was born in Prince William County, Virginia. He was educated in public schools in Nottoway and at Hoge Military Academy in Blackstone before he entered Hampden-Sydney College in 1898. After graduating in 1901, he taught at Homer Military Academy in Oxford, North Carolina (1901-1903); West Kentucky College, Mayfield, Kentucky (1903-1904), and conducted a private collegiate preparatory school in Helena, Arkansas (1904-1906). In 1906, he entered Washington and Lee University’s Law School, was admitted to the bar in 1907 and received his law degree in 1908. During 1907-1908, he practiced law in Lexington while completing his law course.
In 1908, he entered the firm of Epes and Epes at Blackstone and he practiced there until being appointed to the Virginia State Corporation Commission in November 1925. From 1911 to 1918, he was Mayor of Blackstone, resigning in 1918 to enter the United States Army, from which he was honorably discharged on December 5, 1918. In 1919, he was elected to the Virginia State Senate from Nottoway, Lunenburg, Prince Edward, Cumberland and Amelia Counties and served two terms. Epes served on the State Corporation Commission from November 1925 to November 1929, when the governor appointed him to the Supreme Court of Appeals of Virginia. He remained on the bench until his death.