Louie (surname) explained
Louie is an obsolete romanization of the Chinese surname Lei (雷), occasionally still used among speakers of Cantonese or Southern Min dialects
- Alexina Louie (born 1949), Canadian composer
- Janis Louie (born 1971), chemistry professor working at the University of Utah
- Brandt C. Louie (born 1943), Canadian accountant and businessman
- Clarence Louie (born 1960), Canadian First Nations leader and businessman
- David M. Louie (born 1951), American attorney, former Attorney General of Hawaii
- David Wong Louie (born 1954), American novelist, short story writer and essayist.
- Gilman Louie (born 1960), American game designer and venture capitalist
- Juliette Louie (born 1994), Miss Hong Kong 2017 "Lakewood" Louie, American poker player best known for his success at the World Series of Poker in the late 1970s and early 1980s
- Steven Gwon Sheng Louie (born 1949), Canadian Chinese physicist