| Louesme | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason de la ville de Louesme (21).svg |
| Arrondissement: | Montbard |
| Canton: | Châtillon-sur-Seine |
| Insee: | 21357 |
| Postal Code: | 21520 |
| Mayor: | Alain Dosso[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Pays Châtillonnais |
| Coordinates: | 47.8975°N 4.7594°W |
| Elevation M: | 300 |
| Elevation Min M: | 250 |
| Elevation Max M: | 377 |
| Area Km2: | 18.92 |
Louesme (in French pronounced as /lwɛm/) is a commune in the Côte-d'Or department in eastern France.