Lost Creek is a stream in Wayne County in the U.S. state of Missouri. It is a tributary of the St. Francis River.
The stream headwaters occur at the confluence of the West Fork Lost Creek and East Fork Lost Creek at 37.0181°N -90.3069°W currently within Lake Wappapello and the confluence with the St. Francis River is at 36.9844°N -90.3361°W also within Lake Wapapello.[1] [2]
Lost Creek was so named either due to its status as a losing stream or due to a pioneer incident in which a man became lost near its course.[3]