Losoxantrone Explained

Losoxantrone (biantrazole) is an anthroquinone anthrapyrazole antineoplastic agent and analog of mitoxantrone.^{[1] [2]} It is also sometimes known as DuP 941.^[3]

See also

• Mitoxantrone
• Piroxantrone

Notes and References

1. Showalter HD, Johnson JL, Hoftiezer JM, Turner WR, Werbel LM, Leopold WR, Shillis JL, Jackson RC, Elslager EF . 6 . Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias . Journal of Medicinal Chemistry . 30 . 1 . 121–31 . January 1987 . 3806589 . 10.1021/jm00384a021 .
2. Beylin VG, Colbry NL, Goel OP, Haky JE, Johnson DR, Johnson JL, Kanter GD, Leeds RL, Leja B, Lewis EP, Rithner CD . 10.1002/jhet.5570260117. Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI-937, CI-941, and piroxantrone hydrochloride. Journal of Heterocyclic Chemistry. 26. 85–96. 1989 .
3. Leteurtre F, Kohlhagen G, Paull KD, Pommier Y . Topoisomerase II inhibition and cytotoxicity of the anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute preclinical antitumor drug discovery screen . Journal of the National Cancer Institute . 86 . 16 . 1239–44 . August 1994 . 8040892 . 10.1093/jnci/86.16.1239 .