This is a list of the Los Premios MTV Latinoamérica winners and nominees for Video of the Year.
| Year | Winner | Other nominees | |
|---|---|---|---|
| 2002 | Shakira — "Suerte" | ||
| 2003 | Molotov — "Frijolero" | ||
| 2004 | Café Tacuba — "Eres" | ||
| 2005 | Shakira — "La Tortura (featuring Alejandro Sanz)" | ||
| 2006 | Maná — "Labios Compartidos" | ||
| 2007 | Belinda — "Bella Traición" | ||
| 2008 | Belanova — "One, Two, Three, Go! (1, 2, 3, Go!)" | ||
| 2009 | Wisin & Yandel — "Abusadora" |