This is a list of the Los Premios MTV Latinoamérica winners and nominees for Best Artist — South.
| Year | Winner | Other nominees | |
|---|---|---|---|
| 2002 | Diego Torres | ||
| 2003 | Bersuit Vergarabat | ||
| 2004 | Diego Torres | ||
| 2005 | Miranda! | ||
| 2006 | Gustavo Cerati | ||
| 2007 | Airbag | ||
| 2008 | Miranda! | ||
| 2009 | Miranda! |