The Premio 40 Principales for Best Spanish Solo Act was an honor presented annually at Los Premios 40 Principales. For the 2011 edition this award was merged with the Best Group category into the Best Artist/Group award.
| Premios 40 Principales for Best Spanish Solo Act | |
| Awarded For: | Best in Spanish and International music |
| Presenter: | Los 40 Principales |
| Country: | Spain |
| Year: | 2006 |
| Year2: | 2010 |
| Year | Winner | Other nominees |
|---|---|---|
| 2006 | David Bisbal | |
| 2007 | Melendi | |
| 2008 | Melendi | |
| 2009 | Fito & Fitipaldis | |
| 2010 | Dani MartÃn | |