The 2012 event was the seventh edition of Los Premios 40 Principales, created by Los 40 Principales to honor the best in Spanish and international music. For the first time, Los Premios 40 Principales América was run as a separate event.
| Artist(s) | Song(s) | |
|---|---|---|
| Pitbull | "Sube la mano p'arriba" "Don't Stop the Party" | |
| Cali & El Dandee | "Yo te esperaré" "No hay dos sin tres (Gol)" | |
| La Oreja de Van Gogh | "La niña que llora en tus fiestas" "Otra vez me has sacado a bailar" | |
| Auryn | "Don't Give Up My Game" | |
| Pablo Alborán | "Te he echado de menos" "Tanto" | |
| José de Rico Henry Mendez | "Rayos de sol" "Noche de estrellas" | |
| Alejandro Sanz | "No me compares" "Mi marciana" | |
| The Lion King cast | "He Lives in You" | |
| Maldita Nerea | "La respuesta no es la huida" "¿No podíamos ser agua?" | |
| Alicia Keys | "New Day" "Girl on Fire" "Brand New Me" "Looking for Paradise" | |
| Taylor Swift | "Love Story" "We Are Never Ever Getting Back Together" | |
| David Guetta | "Titanium" "She Wolf (Falling to Pieces)" "Just One Last Time" |
Los Premios 40 Principales América is Latin American version of Los Premios 40 Principales. The first edition for awards show was held on November 30, 2012, in Veracruz, Mexico.