| Above: | Los Premios 40 Principales 2011 |
| Label1: | Date |
| Data1: | December 9, 2011 |
| Label2: | Venue |
| Data2: | Palacio de Deportes de la Comunidad de Madrid |
| Label3: | Host |
| Data3: | Tony Aguilar |
| Label4: | Network |
| Data4: | Cuatro (Spain) A&E Network (Latin America) |
This was the sixth edition of Los Premios 40 Principales, created by Los 40 Principales to honor the best in Spanish and international music. It was also the last to feature the national American categories, since Los Premios 40 Principales América would be created for 2012.
| Artist(s) | Song(s) | |
|---|---|---|
| Enrique Iglesias | "I Like How It Feels" "I Like It" "Tonight (I'm Lovin' You)" | |
| Alexandra Stan | "Mr. Saxobeat" "Get Back (ASAP)" | |
| The Wanted | "Glad You Came" | |
| Amaia Montero | "Caminando" | |
| El Pescao | "Castillo de arena" "Buscando el sol" | |
| Marta Sánchez | "Get Together" | |
| Juan Magan | "Bailando por ahí" "No sigue modas" | |
| La Oreja de Van Gogh | "Cometas por el cielo" "El último vals" "La niña que llora en tus fiestas" | |
| Pablo Alborán Malú | "Perdóname" "Solamente tú" "Blanco y negro" | |
| Mohombi | "Coconut Tree" | |
| Shakira | "Antes de las seis" "Devoción" "Loca" | |
| Jessie J | "Price Tag" "Domino" | |
| Carlos Jean | "Gimme the Base" "Pop" "Historia de terror" "Lead the Way" |