| Above: | Los Premios 40 Principales 2010 |
| Label1: | Date |
| Data1: | December 10, 2010 |
| Label2: | Venue |
| Data2: | Palacio de Deportes de la Comunidad de Madrid |
| Label3: | Host |
| Data3: | Mar Montoro, Frank Blanco and Tony Aguilar |
| Label4: | Network |
| Data4: | Cuatro (Spain) A&E Network (Latin America) |
| Artist(s) | Song(s) | |
|---|---|---|
| Kylie Minogue | "Get Outta My Way" "In My Arms" "All the Lovers" | |
| Edward Maya Vika Jigulina | "Stereo Love" | |
| Maldita Nerea | "El secreto de las tortugas" "Tu mirada me hace grande" | |
| Melendi | "Barbie de extrarradio" | |
| Ricky Martin | "Lo mejor de mi vida eres tú" | |
| Nena Daconte | "No te invité a dormir" | |
| Inna | "Hot" "Déjà Vu" | |
| Dani Martín | "16 añitos" | |
| Oceana | "Cry Cry" | |
| Robert Ramírez | "Sick of Love" | |
| Juanes | "Yerbatero" "Y No Regresas" | |
| 40 El Musical cast | "I Gotta Feeling" | |
| Macaco Estopa | "Con la mano levantá" | |
| Alejandro Sanz | "Lola Soledad" "Desde Cuándo" "Looking for Paradise" | |
| Kesha | "Tik Tok" "We R Who We R" |