| Los Amigos River | |
| Map: | Rivers of Madre de Dios.png |
| Mouth Location: | Madre de Dios River |
| Subdivision Type1: | Country |
| Subdivision Name1: | Peru |
The Los Amigos River ("Friends River", Spanish: Río los Amigos) is a river that flows through the Amazon rainforest in the Madre de Dios Region in southeastern Peru. It is a tributary of the 1,347 km long Madre de Dios River.