Lorna Casselton Explained

Birth Name:	Lorna Ann Smith
Birth Date:	1938 7, df=yes^[1]
Birth Place:	Rochford, Essex, England
Death Place:	Oxford, England
Alma Mater:	University College London
Thesis Title:	The production, behaviour and genetics of diploids of Coprinus lagopus
Thesis Url:	http://www.theses.com/idx/scripts/it3.asp?xml=Z:\index\idx\docs\all\14\it00349998.htm
Thesis Year:	1964
Doctoral Advisor:	Dan Lewis^[2] ^[3]
Known For:	Genetic and molecular analysis of mushrooms

Lorna Ann Casselton, (18 July 1938 – 14 February 2014) was a British academic and biologist. She was Professor Emeritus of Fungal Genetics in the Department of Plant Science at the University of Oxford, and was known for her genetic and molecular analysis of the mushroom Coprinus cinereus^[4] and Coprinus lagopus.^{[5] [6] [7] [8] [9]}

Early life

Casselton was born on 18 July 1938 in Rochford, Essex^[10] to William Charles Henry Smith and Cecile Smith (née Bowman). Her parents' smallholding and her father's interest in natural history and genetics encouraged her and her sister Pauline in the direction of biology. She was educated at Southend High School for Girls, a grammar school in Southend-on-Sea.^[11] She studied at University College London, from which she gained a Bachelor of Science (BSc) degree in botany and a Doctor of Philosophy (PhD) degree in 1964.^{[8] [12] [13]}

Academic career

Casselton began her career in lecturing and research as an assistant lecturer at Royal Holloway College in London. She was Professor of Genetics at Queen Mary University of London from 1989 to 1991 and was later awarded an AFRC/BBSRC Postdoctoral Fellowship, followed by a BBSRC Senior Research Fellowship in 1995.

Casselton was a Fellow of St Cross College Oxford from 1993 to 2003, and was appointed Professor of Fungal Genetics at Oxford in 1997. Her specialism was sexual development in fungi and she contributed to over 100 publications on this topic. She was a Fellow of St Cross College, Oxford, from 1993 to 2003, and an Honorary Fellow of St Hilda's College, Oxford, from 2000. She was a member of the Royal Society's Council from 2002 to 2003, and rejoined the Council in 2006 as Vice-President and Foreign Secretary, replacing Professor Dame Julia Higgins.^{[14] [15]}

As Foreign Secretary of the Royal Society, Casselton gave the Royal Society Rutherford Lecture in South Africa and the Blackett Lecture in India, travelling to 27 different countries during three and a half years in office.

Personal life

She married Peter John Casselton in 1961, divorcing him in 1978. She married William Joseph Dennis Tollett in 1981.^[1] She died after a short illness, aged 75.^[16]

Awards and honours

She was elected a Fellow of the Royal Society in 1999. She became a Member of the Academia Europaea in 2008, and was awarded an Honorary Doctor of Science by Queen Mary College, University of London in 2009 and University College London in September 2010.^[17] She was appointed Commander of the Order of the British Empire (CBE) in the 2012 Birthday Honours for services to fungal genetics and international science. Her nomination for the Royal Society reads:

The British Mycological Society awarded her an Honorary Membership in 2002.

Selected publications

• Stajich . J. E. . Wilke . S. K. . Ahren . D. . Au . C. H. . Birren . B. W. . Borodovsky . M. . Burns . C. . Canback . B. . Casselton . L. A. . Cheng . C. K. . Deng . J. . Dietrich . F. S. . Fargo . D. C. . Farman . M. L. . Gathman . A. C. . Goldberg . J. . Guigo . R. . Hoegger . P. J. . Hooker . J. B. . Huggins . A. . James . T. Y. . Kamada . T. . Kilaru . S. . Kodira . C. . Kues . U. . Kupfer . D. . Kwan . H. S. . Lomsadze . A. . Li . W. . Lilly . W. W. . Ma . L.-J. . Mackey . A. J. . Manning . G. . Martin . F. . Muraguchi . H. . Natvig . D. O. . Palmerini . H. . Ramesh . M. A. . Rehmeyer . C. J. . Roe . B. A. . Shenoy . N. . Stanke . M. . Ter-Hovhannisyan . V. . Tunlid . A. . Velagapudi . R. . Vision . T. J. . Zeng . Q. . Zolan . M. E. . Pukkila . P. J. . 4 . Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus) . Proceedings of the National Academy of Sciences . 107 . 26 . 14 June 2010 . 0027-8424 . 2900686 . 10.1073/pnas.1003391107 . 11889–11894. 20547848 . free .
• Riquelme . Meritxell . Challen . Michael P. . Casselton . Lorna A. . Brown . Andrew J. . The Origin of MultipleBMating Specificities inCoprinus cinereus . Genetics . Oxford University Press (OUP) . 170 . 3 . 6 May 2005 . 0016-6731 . 10.1534/genetics.105.040774 . 1105–1119. 15879506 . 1451185 . free .
• Casselton . LA. . 2002 . Mate recognition in fungi . Heredity . 88 . 2. 142–147 . 10.1038/sj.hdy.6800035 . 11932772. free .
• Brown . AJ . Casselton . LA. . 2001 . Mating in mushrooms: increasing the chances but prolonging the affair . Trends in Genetics . 17 . 7 . 393–400 . 10.1016/s0168-9525(01)02343-5 . 11418220.
• Olesnicky . NS. . Brown . AJ. . Dowell . SJ. . Casselton . LA. . 1999 . A constitutively active G-protein-coupled receptor causes mating self-compatibility in the mushroom Coprinus . EMBO Journal . 18 . 10 . 2756–2763 . 10.1093/emboj/18.10.2756. 10329622 . 1171357 .
• Casselton . LA. . Olesnicky . NS. . 1998 . Molecular genetics of mating recognition in basidiomycete fungi . 9529887. Microbiology and Molecular Biology Reviews . 62 . 1 . 55–70 . 98906 . 10.1128/mmbr.62.1.55-70.1998.
• Banham . AH. . Asanteowusu . RN. . Casselton . LA. . 1995 . An N-terminal dimerization domain permits homeodomain proteins to choose compatible partners and initiate sexual development in the mushroom Coprinus cinereus . Plant Cell . 7 . 6 . 773–783 . 10.1105/tpc.7.6.773 . 12242384 . 160831.
• Kues . U. . Casselton . LA. . 1992 . Fungal mating type genes - regulators of sexual development . Mycological Research . 96 . 12 . 993–1006 . 10.1016/s0953-7562(09)80107-x.
• Kues . U. . Richardson . WVJ . Casselton . LA. . 1992 . The combination of dissimilar alleles of the A-alpha and A-beta gene complexes, whose proteins contain homeo domain motifs, determines sexual development in the mushroom Coprinus cinereus . Genes & Development . 6 . 4 . 568–577 . 10.1101/gad.6.4.568. 1348484 . free .
• Binninger . DM. . Skrzynia . C. . Pukkila . PJ. . Casselton . LA. . 1987 . DNA-mediated transformation of the basidiomycete Coprinus cinereus . EMBO Journal . 6 . 4 . 835–840 . 10.1002/j.1460-2075.1987.tb04828.x . 3595558 . 553472 .
• Sealy-Lewis . HM. . Casselton . LA. . 1978 . Restoration of enzyme activity by recessive missense suppressors in fungus Coprinus . Molecular and General Genetics . 164 . 2 . 211–215 . 10.1007/bf00267386. 30040 . 6010171 .
• Casselton . LA. . Lewis . D. . Dilution of gene products in cytoplasm of heterokaryons in Coprinus lagopus". . Genetical Research . 9 . 63 . 10.1017/s0016672300010314 . 1967. free .
• Casselton . LA. . 1965 . Production and behaviour of diploids of Coprinus lagopus . Genetical Research . 6 . 2 . 190–208 . 10.1017/s0016672300004080 . 14345906. free .

Notes and References

1. Web site: CASSELTON, Prof. Lorna Ann, (Mrs W. J. D. Tollett) . Who's Who 2014, A & C Black, an imprint of Bloomsbury Publishing plc, 2014; online edn, Oxford University Press.
2. Casselton . L. A. . Lorna Casselton. Jones . D. A. . Dan Lewis. 30 December 1910 – 30 September 2009 . 10.1098/rsbm.2011.0023 . . 2012 . 58 . 163–178. 85390625 .
3. http://www.ucl.ac.uk/gee/gee-news-publication/news-2014/lorna-casselton-1938-2014 Professor Lorna Casselton CBE FRS
4. Casselton . L. A. . Lorna Casselton. Olesnicky . N. S. . Molecular genetics of mating recognition in basidiomycete fungi . Microbiology and Molecular Biology Reviews . 62 . 1 . 55–70 . 1998 . 9529887 . 98906 . 10.1128/mmbr.62.1.55-70.1998.
5. 10.1017/S0016672300004080. The production and behaviour of diploids of Coprinus lagopus. Genetical Research. 6. 2. 190–208. 2009. Casselton . L. A.. 14345906 . free.
6. Lewis . D. . Casselton . L. A. . Lorna Casselton. Missense suppression in Coprinus lagopus associated with a chromosome duplication . Journal of General Microbiology . 88 . 1 . 20–26 . 1975 . 1097583 . 10.1099/00221287-88-1-20. free .
7. Casselton . L. A. . Lorna Casselton. Lewis . D. . Compatibility and stability of diploids in Coprinus lagopus . Genetical Research . 8 . 1 . 61–72 . 1966 . 5947646 . 10.1017/s0016672300009915. free .
8. http://www.debretts.com/people/biographies/browse/c/20689/Lorna%20Ann%20(Mrs%20Tollett)+CASSELTON.aspx Casselton's profile
9. https://www.theguardian.com/science/2014/mar/31/lorna-casselton Lorna Casselton obituary: Researcher into the genetic basis of fungal mating
10. https://www.theguardian.com/science/2014/mar/31/lorna-casselton Lorna Casselton obituary
11. News: Professor Lorna Casselton. 28 March 2014. The Times. 27 March 2014.
12. PhD . Lorna. Casselton . The production, behaviour and genetics of diploids of Coprinus lagopus . University College London . 1964 . Lorna Casselton.
13. 10.1007/BF00332815. Suppression of methionine mutants in Coprinus. MGG Molecular & General Genetics. 134. 85–92. 1974. Shahriari . H.. Casselton . L. A. . 11520048.
14. http://royalsociety.org/people/lorna-casselton/ Casselton's biography on the Royal Society website
15. Web site: Plant Sciences Staff Professor Lorna A. Casselton . 1 March 2012 . https://web.archive.org/web/20120301224239/http://dps.plants.ox.ac.uk/plants/(A(ougeXgycyQEkAAAAZGE3YzhiNTEtZjdiMy00MGM3LWIzY2EtNTZjMDk3ZmUxNTYxoaBsFUv7gBLrrH8TmuqmivY5Vso1))/staff/LornaCasselton.aspx . dead .
16. http://www.stx.ox.ac.uk/about-st-cross/news/professor-lorna-casselton-cbe-ma-dsc-frs St Cross College, Oxford
17. Web site: Staff . Honorary Graduates of UCL . University College London . 23 October 2012 . https://web.archive.org/web/20160812054732/https://www.ucl.ac.uk/about-ucl/who-we-are/honorary-graduates . 12 August 2016 . dead .