Lori Passmore Explained

Lori Passmore
Birth Name:Lori Anne Passmore
Nationality:Canadian/British
Thesis Url:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406167
Thesis Title:Structural and functional studies of the anaphase promoting complex (APC)
Thesis Year:2003
Doctoral Advisor:David Barford
Academic Advisors:Venki Ramakrishnan
Richard Henderson

Lori Anne Passmore is a Canadian/British cryo electron microscopist and structural biologist who works at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge. She is known for her work on multiprotein complexes involved in gene expression[1] [2] [3] and development of new supports for cryo-EM.[4]

Education

Lori Passmore graduated from the University of British Columbia, Canada in 1999.[5] She obtained a PhD in 2003 from University of London for research supervised by David Barford at the Institute of Cancer Research. She performed in vitro biochemical characterisation of the activity of the anaphase-promoting complex (APC)[6] and used cryo-EM to study the APC structure.[7] [8]

Career and research

Passmore worked as a postdoctoral researcher at the MRC-LMB. She worked with Venki Ramakrishnan and Richard Henderson, using cryo-EM to determine the structure of the eukaryotic ribosome bound to initiation factors.[9] Passmore became a group leader at the MRC-LMB in 2009. Her group uses in vitro reconstitution, biochemical assays and cryo-EM to understand the function of multiprotein complexes that regulate gene expression at the level of mRNA. Her group has developed new sample grids for cryo-EM that reduce specimen movement during imaging. In collaboration with Ketan J. Patel, Passmore is also actively studying the molecular mechanisms underlying Fanconi anemia.[10] [11]

Grants, awards and honours

Notes and References

  1. Wolf J, Valkov E, Allen MD, Meineke B, Gordiyenko Y, McLaughlin SH, Olsen TM, Robinson CV, Bycroft M, Stewart M, Passmore LA . Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation . The EMBO Journal . 33 . 14 . 1514–26 . 2014 . 24872509 . 4158885 . 10.15252/embj.201488373 .
  2. Casañal A, Kumar A, Hill CH, Easter AD, Emsley P, Degliesposti G, Gordiyenko Y, Santhanam B, Wolf J, Wiederhold K, Dornan GL, Skehel M, Robinson CV, Passmore LA . Architecture of eukaryotic mRNA 3'-end processing machinery . Science . 358 . 6366 . 1056–1059 . 2017 . 29074584 . 5788269 . 10.1126/science.aao6535 .
  3. Stowell JA, Webster MW, Kögel A, Wolf J, Shelley KL, Passmore LA . Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1 . Cell Reports . 17 . 8 . 1978–1989 . 2016 . 27851962 . 5120349 . 10.1016/j.celrep.2016.10.066 .
  4. Russo CJ, Passmore LA . Electron microscopy: Ultrastable gold substrates for electron cryomicroscopy . Science . 346 . 6215 . 1377–80 . 2014 . 25504723 . 4296556 . 10.1126/science.1259530 .
  5. Web site: Dr. Lori Anne Passmore - AcademiaNet. www.academia-net.org. 2018-06-08.
  6. Passmore LA, McCormack EA, Au SW, Paul A, Willison KR, Harper JW, Barford D . Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition . The EMBO Journal . 22 . 4 . 786–96 . 2003 . 12574115 . 145444 . 10.1093/emboj/cdg084 .
  7. Lori Anne. Passmore. Structural and functional studies of the anaphase promoting complex (APC). 2003. . 500247667. University Of London. london.ac.uk. PhD.
  8. Passmore LA, Booth CR, Vénien-Bryan C, Ludtke SJ, Fioretto C, Johnson LN, Chiu W, Barford D . Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation . Molecular Cell . 20 . 6 . 855–66 . 2005 . 16364911 . 10.1016/j.molcel.2005.11.003 . free .
  9. Passmore LA, Schmeing TM, Maag D, Applefield DJ, Acker MG, Algire MA, Lorsch JR, Ramakrishnan V . The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome . Molecular Cell . 26 . 1 . 41–50 . 2007 . 17434125 . 10.1016/j.molcel.2007.03.018 . free .
  10. Rajendra E, Garaycoechea JI, Patel KJ, Passmore LA . 2014 . Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases . Nucleic Acids Research . 42 . 22 . 13736–13748 . 4267650. 10.1093/nar/gku1230 . 25428364.
  11. Rajendra E, Oestergaard VH, Langevin F, Wang M, Dornan GL, Patel KJ, Passmore LA . 2014 . The Genetic and Biochemical Basis of FANCD2 Monoubiquitination . Molecular Cell . 54 . 5 . 858–869 . 10.1016/j.molcel.2014.05.001 . 24905007 . 4051986 .
  12. Web site: Dr Lori A Passmore Clare Hall. www.clarehall.cam.ac.uk. 2018-06-08.
  13. News: Twenty-seven researchers named as EMBO Young Investigators. 2018. EMBO. 2018-06-08. en-gb.
  14. Web site: Celebrating women in science on Ada Lovelace Day 2016. suffragescience.org. 2018-06-08.
  15. Web site: List of ERC consolidator grant awardees 2016 .
  16. News: 62 life scientists elected as EMBO Members. EMBO. EMBO. 2018-06-08. en-gb.
  17. Web site: Find people in the EMBO Communities. people.embo.org. 2018-06-08.
  18. Web site: Hanadi Sleiman . 2023-05-24 . royalsociety.org.

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