Lori Ann Setton Explained

Lori Ann Setton
Birth Place:Queens, New York, US
Nationality:American
Fields:Biomechanical Engineer
Workplaces:Washington University in St. Louis, Duke University
Alma Mater:Princeton University
Columbia University
Doctoral Advisor:Van C. Mow
Known For:mechanics
mechanobiology of the intervertebral disc
articular cartilagemechanics
drug delivery
pathomechanisms of osteoarthritis
Awards:AIMBE Fellow (2005)
BMES Fellow (2009)
Van C. Mow Medal(2007)

Lori Ann Setton is an American biomechanical engineer noted for her research on mechanics and mechanobiology of the intervertebral disc, articular cartilage mechanics, drug delivery, and pathomechanisms of osteoarthritis. She is currently the department chair as well as the Lucy and Stanley Lopata Distinguished Professor of Biomedical Engineering at McKelvey School of Engineering at Washington University in St. Louis.

Biography

Setton was born in Queens, New York. She received a B.S.E. in Mechanical and Aerospace Engineering from Princeton University in 1984. Subsequently, she pursued graduate degrees under the tutelage of Professor Van C. Mow at Columbia University. She received an M.S. degree and Ph.D degree in Mechanical Engineering/Biomechanics in 1988 and 1993, respectively.

She joined the Department of Biomedical Engineering at Duke University as an assistant professor in 1995. Promotions to tenured associate professor in and professor followed in 2004 and 2007.

Her most noticeable work has documented the biological responses of cartilage and intervertebral disc to mechanical loading,[1] [2] [3] [4] [5] [6] understanding a role for collagen genetic mutations in onset of arthritis and intervertebral disc pathology,[7] [8] development of injectable hydrogels for articular cartilage repair,[9] [10] [11] [12] and development of injectable drug delivery vehicles for fighting inflammation in musculoskeletal disease.[13] [14] [15] [16] [17] As of June 1, 2017, her work has been cited over 17,500 times.[18] She has an h-index of 65.

Awards

Setton has several awards:

External links

Notes and References

  1. Setton . LA . Chen . J . 2006 . Mechanobiology of the intervertebral disc and relevance to disc degeneration . J Bone Joint Surg Am . 88 . 52–57 . 16595444 . 2 . 10.2106/JBJS.F.00001 . (cited 154 times)
  2. Setton . LA . Mow . VC . Müller . FJ . Pita . JC . Howell . DS . 1994 . Mechanical properties of canine articular cartilage are significantly altered following transection of the anterior cruciate ligament . Journal of Orthopaedic Research . 12 . 451–463 . 8064477 . 4 . 10.1002/jor.1100120402 . 41257875 . (cited 168 times)
  3. LeRoux . MA . Arokoski . J . Vail . TP . Guilak . F . Hyttinen . MM . Kiviranta . I . Setton . LA . 2000 . Simultaneous changes in the mechanical properties, quantitative collagen organization, and proteoglycan concentration of articular cartilage following canine meniscectomy . Journal of Orthopaedic Research . 18 . 383–392 . 10937624 . 3 . 10.1002/jor.1100180309 . 1697626 . (cited 122 times)
  4. Leroux, MA . Cheung, HS . Bau, JL . Wang, JY . Howell, DS . Setton, LA . 2001 . Altered mechanics and histomorphometry of canine tibial cartilage following joint immobilization . Osteoarthritis and Cartilage . 9 . 633–640 . 11597176 . 7 . 10.1053/joca.2001.0432 . free . (cited 62 times)
  5. Boyd, LM . Richardson, WJ . Chen, J . Kraus, VB . Tewari, A . Setton, LA . 2005 . Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR . Annals of Biomedical Engineering . 33 . 1071–1077 . 16133915 . 8 . 10.1007/s10439-005-5775-y . 10.1.1.419.5226 . 18286177 . (cited 35 times)
  6. Chen, J . Yan, W . Setton, LA . 2004 . Static compression induces zonal-specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in vitro . Matrix Biology . 22 . 573–583 . 14996437 . 7 . 10.1016/j.matbio.2003.11.008 . (cited 74 times)
  7. Boyd, LM . Richardson, WJ . Allen, KD . Flahiff, C . Jing, L . Li, Y . Chen, J . Setton, LA . 2008 . Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen . Arthritis Rheum . 58 . 164–171 . 18163498 . 1 . 10.1002/art.23231 . free . (cited 40 times)
  8. Allen, KD . Griffin, TM . Rodriguiz, RM . Wetsel, WC . Kraus, VB . Huebner, JL . Boyd LM . Setton, LA . 2009 . Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen . Arthritis Rheum . 60 . 2684–2693 . 9 . 10.1002/art.24783 . 2760314 . 19714629 . (cited 29 times)
  9. Nettles, DL . Chilkoti, A . Setton, LA . 2010 . Applications of elastin-like polypeptides in tissue engineering . Adv Drug Deliv Rev . 62 . 1479–1485 . 20385185 . 15 . 10.1016/j.addr.2010.04.002 . 2935943 . (cited 114 times)
  10. Nettles DL . Kitaoka, K . Hanson, NA . Flahiff, CM . Mata, BA . Hsu, EW . Chilkoti, A . Setton, LA . 2008 . In situ crosslinking elastin-like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect model . Tissue Eng Part A . 14 . 1133–1140 . 18433311 . 7 . 3312393 . 10.1089/tea.2007.0245 . (cited 50times)
  11. Betre, H . Ong, SR . Guilak, F . Chilkoti, A . Fermor, B . Setton, LA . 2006 . Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide . Biomaterials . 27 . 91–99 . 16023192 . 1 . 10.1016/j.biomaterials.2005.05.071 .
  12. Nettles, DL . Vail, TP . Morgan, MT . Grinstaff, MW . Setton, LA . 2004 . Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair . Ann Biomed Eng . 32 . 391–397 . 15095813 . 3 . 10.1023/b:abme.0000017552.65260.94 . 2024-05-17 . 1334471 .
  13. Allen, KD . Adams, SB Jr . Mata, BA . Shamji, MF . Gouze, E . Jing, L . Nettles, DL . Latt, LD . Setton, LA . 2010 . Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist . Journal of Orthopaedic Research . 29 . 694–703 . 21437948 . 5 . 3100769 . 10.1002/jor.21309 .
  14. Shamji, MF . Chen, J . Friedman, AH . Richardson, WJ . Chilkoti, A . Setton, LA . 2008 . Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist . J Control Release . 129 . 179–186 . 18547669 . 3 . 2637771 . 10.1016/j.jconrel.2008.04.021 .
  15. Shamji, MF . Betre, H . Kraus, VB . Chen, J . Chilkoti, A . Pichika, R . Masuda, K . Setton LA . 2007 . Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic . Arthritis Rheum . 56 . 3650–3661 . 17968946 . 11 . 10.1002/art.22952 . 32108692 .
  16. Betre, H . Liu, W . Zalutsky, MR . Chilkoti, A . Kraus, VB . Setton, LA . 2006 . A thermally responsive biopolymer for intra-articular drug delivery . J Control Release . 115 . 175–182 . 16959360 . 2 . 10.1016/j.jconrel.2006.07.022 .
  17. Allen, KD . Shamji, MF . Mata, BA . Gabr, MA . Sinclair, SM . Schmitt, DO . Richardson, WJ . Setton LA . 2011 . Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism . . 13 . R137 . 21871102 . 4 . 3239380 . 10.1186/ar3451 . free .
  18. https://scholar.google.com/citations?user=HUxQ1TAAAAAJ&hl=en Google Scholar Citations for Lori Setton
  19. Web site: Duke University Graduate School . Dean's Awards for Excellence in Mentoring: Past Recipients . gradschool.duke.edu . 2005 . 2013-05-22 . dead . https://web.archive.org/web/20131020032831/http://www.aimbe.org/members/college-of-fellows/ . 2013-10-20.
  20. Web site: bmes.org . BMES Fellows . Biomedical Engineering Society . 2009 . 2013-05-23.
  21. Web site: asme.org . Van C. Mow Medal Recipients . American Society of Mechanical Engineers . 2007 . 2013-05-23.
  22. Web site: All Fellows. ASME. 2022.
  23. Web site: www.nsf.gov . Twenty NSF-Supported Young Scientists and Engineers Receive Presidential Award . National Science Foundation . 1997-10-24 . 2013-05-25.

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