| Lorenza Villegas de Santos | |
| Office: | First Lady of Colombia |
| Term Label: | In role |
| President: | Eduardo Santos Montejo |
| Predecessor: | María Michelsen de López |
| Successor: | María Michelsen de López |
| Birth Date: | 5 October 1899 |
| Birth Name: | Ana Lorenza Villegas Restrepo |
| Birth Place: | Santa Rosa de Cabal, Risaralda, Colombia |
| Death Place: | New York City, New York, U.S. |
| Nationality: | Colombian |
| Party: | Liberal |
| Children: | Clara Santos Villegas |
Ana Lorenza Villegas de Santos (née Villegas Restrepo; 5 October 1899[1] – 25 March 1960) was the wife of the 15th President, Eduardo Santos Montejo, and served as First Lady of Colombia from 1938 to 1942.[2]
Ana Lorenza Villegas Restrepo born 5 October 1899 in Santa Rosa de Cabal, at that time Caldas, currently Risaralda[3] to José Antonio Villegas y Villegas and Carlota Restrepo Botero. On 25 November 1917[4] she married Eduardo Santos Montejo, whom she had met through her brother, Alfonso Villegas, founder and owner of El Tiempo who sold the newspaper to Santos in 1913. Together they had one daughter, Clara, who died of scarlet fever at the age of three. Lorenza died on 25 March 1960 in New York City.[5] [6] [7]