Loperamide/simethicone explained

Type:combo
Component1:Loperamide
Class1:Antidiarrheal
Component2:Simethicone
Class2:Gas reducer
Tradename:Imodium Multi-Symptom Relief, Imodium Plus, Imodium Plus Comfort
Dailymedid:Loperamide and simethicone
Pregnancy Au:B3
Routes Of Administration:By mouth
Atc Prefix:A07
Atc Suffix:DA53
Legal Uk:P
Legal Uk Comment:/ GSL
Legal Us:OTC

Loperamide/simethicone is combination medication sold under the brand name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously. It is manufactured by the McNeil Consumer Healthcare Division of McNeil PPC, Inc. It contains loperamide and simethicone.

Loperamide is a μ-opioid receptor agonist that works in the intestines.[1] Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal lumen.

Simethicone reduces gas by allowing smaller gas bubbles to coalesce into larger bubbles in the intestinal tract, making them easier to pass. Simethicone is not absorbed from the gastrointestinal tract so there are no systemic side effects.[2] [3]

Notes and References

  1. https://www.drugs.com/cons/imodium-a-d.html Imodium
  2. https://www.drugs.com/mtm/simethicone.html Simethicone
  3. Web site: Bloody Diarrhea . 2013-02-11.