Long-chain acyl-CoA dehydrogenase explained

Long-chain acyl-CoA dehydrogenase
Ec Number:	1.3.8.8
Cas Number:	59536-74-2
Go Code:	0004466

Long-chain acyl-CoA dehydrogenase (palmitoyl-CoA dehydrogenase, palmitoyl-coenzyme A dehydrogenase, long-chain acyl-coenzyme A dehydrogenase, long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase, ACADL (gene).) is an enzyme with systematic name long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase.^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

\rightleftharpoons a long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein

This enzyme contains FAD as prosthetic group and participates in fatty acid metabolism and PPAR signaling pathway.^[6] Mitochondrial mutations in this enzyme may be associated with some forms of dilated cardiomyopathy.

Notes and References

1. Crane FL, Hauge JG, Beinert H . Flavoproteins involved in the first oxidative step of the fatty acid cycle . Biochimica et Biophysica Acta . 17 . 2 . 292–4 . June 1955 . 13239683 . 10.1016/0006-3002(55)90374-7 .
2. Hauge JG, Crane FL, Beinert H . On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. III. Palmityl coA dehydrogenase . The Journal of Biological Chemistry . 219 . 2 . 727–33 . April 1956 . 10.1016/S0021-9258(18)65732-1 . 13319294 . free .
3. Hall CL, Heijkenskjöld L, Bártfai T, Ernster L, Kamin H . Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef hart mitochondria . Archives of Biochemistry and Biophysics . 177 . 2 . 402–14 . December 1976 . 1015826 . 10.1016/0003-9861(76)90453-7 .
4. Ikeda Y, Okamura-Ikeda K, Tanaka K . Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme . The Journal of Biological Chemistry . 260 . 2 . 1311–25 . January 1985 . 10.1016/S0021-9258(20)71245-7 . 3968063 . free .
5. Djordjevic S, Dong Y, Paschke R, Frerman FE, Strauss AW, Kim JJ . Identification of the catalytic base in long chain acyl-CoA dehydrogenase . Biochemistry . 33 . 14 . 4258–64 . April 1994 . 8155643 . 10.1021/bi00180a021 .
6. Ezzeddini R, Taghikhani M, Salek Farrokhi A, Somi MH, Samadi N, Esfahani A, Rasaee, MJ . Downregulation of fatty acid oxidation by involvement of HIF-1α and PPARγ in human gastric adenocarcinoma and its related clinical significance . Journal of Physiology and Biochemistry . 77 . 2 . 249–260 . May 2021 . 33730333 . 10.1007/s13105-021-00791-3 . 232300877 .