Long-chain-fatty-acyl-CoA reductase explained

long-chain-fatty-acyl-CoA reductase
Ec Number:	1.2.1.50
Cas Number:	50936-56-6
Go Code:	0050062

In enzymology, a long-chain-fatty-acyl-CoA reductase is an enzyme that catalyzes the chemical reaction

a long-chain aldehyde + CoA + NADP⁺

\rightleftharpoons a long-chain acyl-CoA + NADPH + H⁺

The 3 substrates of this enzyme are long-chain aldehyde, CoA, and NADP⁺, whereas its 3 products are long-chain acyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming). Other names in common use include acyl-CoA reductase, and acyl coenzyme A reductase.

References

• Riendeau D, Rodriguez A, Meighen E . 1982 . Resolution of the fatty acid reductase from Photobacterium phosphoreum into acyl protein synthetase and acyl-CoA reductase activities. Evidence for an enzyme complex . J. Biol. Chem. . 257 . 6908 - 15 . 7085612 . 12 .
• Wall L . Meighen EA . 1986 . Subunit structure of the fatty-acid reductase complex from Photobacterium phosphoreum . Biochemistry . 25 . 4315 - 4321 . 10.1021/bi00363a021 . 15 .