Long-chain-fatty-acid—luciferin-component ligase explained

Long-chain-fatty-acid—luciferin-component ligase
Ec Number:	6.2.1.19
Cas Number:	82657-98-5
Go Code:	0047474

In enzymology, a long-chain-fatty-acid—luciferin-component ligase is an enzyme that catalyzes the chemical reaction

ATP + an acid + protein

\rightleftharpoons AMP + diphosphate + an acyl-protein thioester

The 3 substrates of this enzyme are ATP, acid, and protein, whereas its 3 products are AMP, diphosphate, and acyl-protein thioester.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is long-chain-fatty-acid:protein ligase (AMP-forming). This enzyme is also called acyl-protein synthetase.

References

• Riendeau D, Rodriguez A, Meighen E . 1982 . Resolution of the fatty acid reductase from Photobacterium phosphoreum into acyl protein synthetase and acyl-CoA reductase activities. Evidence for an enzyme complex . J. Biol. Chem. . 257 . 6908 - 15 . 7085612 . 12 . 10.1016/S0021-9258(18)34515-0 . free .
• Wall L . Meighen EA . 1986 . Subunit structure of the fatty-acid reductase complex from Photobacterium phosphoreum . Biochemistry . 25 . 15 . 4315 - 4321 . 10.1021/bi00363a021 .