Long-chain-enoyl-CoA hydratase explained

long-chain-enoyl-CoA hydratase
Ec Number:	4.2.1.74
Cas Number:	62009-81-8
Go Code:	0016508

The enzyme long-chain-enoyl-CoA hydratase catalyzes the chemical reaction

(3S)-3-hydroxyacyl-CoA

\rightleftharpoons trans-2-enoyl-CoA + H₂O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase. This enzyme is also called long-chain enoyl coenzyme A hydratase. This enzyme participates in fatty acid elongation in mitochondria and fatty acid metabolism.

References

• Fong JC, Schulz H . 1977 . Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues . J. Biol. Chem. . 252 . 542 - 7 . 833142 . 2 .
• Schulz H . 1974 . Long chain enoyl coenzyme A hydratase from pig heart . J. Biol. Chem. . 249 . 2704 - 9 . 4828315 . 9 .