Lone Gram Explained

Lone Gram
Alma Mater:Royal Veterinary and Agricultural University
Thesis Title:Identification, characterization, and inhibition of bacteria isolated from tropical fish
Thesis Url:https://www.worldcat.org/oclc/
Thesis Year:1989

Lone Gram is Danish microbiologist known for her work in bacterial physiology, microbial communication, and biochemicals that originate from bacterial cultures. She is an elected member of the Royal Danish Academy of Sciences and Letters and has received the Order of the Dannebrog.

Education and career

Gram's first microbiology course led her away from her initial career interests in medicine,[1] and into marine bacteria.[2] Gram has both an M.Sc. (1985)[3] and a Ph.D. (1989) from the Royal Veterinary and Agricultural University in Denmark.[4] Following her Ph.D., Gram joined the Technological Laboratory of the Danish Ministry of Fishes. In 2010 she was promoted to professor at the Technical University of Denmark. Gram has also spent time working at Harvard Medical School and at the University of New South Wales.

Research

Gram's research centers on the physiology of bacteria in the environment and using bacteria for biotechnology. Her early research examined variability in the bacteria found in spoiled fish,[5] [6] [7] removing bacterial biofilms,[8] and preventing biofilms using compounds from the red algae Delisea pulchra.[9] She has examined the interactions across different species of bacteria,[10] and the production of compounds that send messages among bacteria.[11] Her research includes investigations bacterial attachment to surfaces,[12] and quantification of hydrogen sulfide production by bacteria associated with fish.[13] From 2006 until 2007, Gram participated in the Galathea 3 expeditions,[14] and she is using the bacterial cultures initiated during the project to mine bacteria for chemical compounds that may be useful to people.[15] Gram's research extends to investigations of the global distribution of bacterial species,[16] and an examination of how the presence of varying nutrients alters the chemical compounds produced by bacteria.[17]

Selected publications

Awards and honors

In 2008, Gram received Tagea Brandt Rejselegat, an award given to Danish women to recognize significant contributions in science, literature, or art. In 2016, Gram received the Villum Kann Rasmussen Annual Award in Science and Technology, which is given in recognition of "a particularly valuable contribution to the technical and natural sciences".[18] In 2018, she received the Order of the Dannebrog.[19] In 2020, Gram was elected a member of the Royal Danish Academy of Sciences and Letters.[20]

Personal life

Gram's great-grandfather[21] was Hans Christian Gram who developed the Gram stain, a commonly used technique in microbial ecology.[22] Gram is also distantly related to the Danish historian Hans Gram.[1]

Notes and References

  1. Web site: March 31, 2021. Lone Gram Royal Academy. 2022-01-15. www.royalacademy.dk.
  2. Web site: Professor Lone Gram. 2022-01-15. www.royalacademy.dk.
  3. Konduktansmaling og mikrokalorimetri som hurtigmetoder i levnedsmiddelhygiejne: en undersgelse af fersk fisk. Institut for Veterinr Mikrobiologi og Hygiejne, KVL. 1985. Kobenhavn. Danish. Lone. Gram. 476091721.
  4. Identification, characterization, and inhibition of bacteria isolated from tropical fish. 1989. Copenhagen, Denmark. Lone. Gram. 222426373.
  5. Gram. Lone. Trolle. Gunilla. Huss. Hans Henrik. 1987-01-01. Detection of specific spoilage bacteria from fish stored at low (0°C) and high (20°C) temperatures. International Journal of Food Microbiology. en. 4. 1. 65–72. 10.1016/0168-1605(87)90060-2. 0168-1605.
  6. Gram. L.. 1993. Inhibitory effect against pathogenic and spoilage bacteria of Pseudomonas strains isolated from spoiled and fresh fish. Applied and Environmental Microbiology. 59. 7. 2197–2203. EN. 10.1128/aem.59.7.2197-2203.1993. 8357253. 182257. 1993ApEnM..59.2197G.
  7. Gram. Lone. Huss. Hans Henrik. 1996-11-01. Microbiological spoilage of fish and fish products. International Journal of Food Microbiology. Specific Spoilage Organisms. en. 33. 1. 121–137. 10.1016/0168-1605(96)01134-8. 8913813. 0168-1605.
  8. Johansen. C.. Falholt. P.. Gram. L.. 1997. Enzymatic removal and disinfection of bacterial biofilms. Applied and Environmental Microbiology. 63. 9. 3724–3728. EN. 10.1128/aem.63.9.3724-3728.1997. 9293025. 168680. 1997ApEnM..63.3724J.
  9. Maximilien. R. de Nys. R. Holmström. C. Gram. L. Givskov. M. Crass. K. Kjelleberg. S. Steinberg. Pd. 1998. Chemical mediation of bacterial surface colonisation by secondary metabolites from the red alga Delisea pulchra. Aquatic Microbial Ecology. en. 15. 233–246. 10.3354/ame015233. 0948-3055. free.
  10. Gram. Lone. Melchiorsen. Jette. Spanggaard. Bettina. Huber. Ingrid. Nielsen. Torben F.. 1999-03-01. Inhibition of Vibrio anguillarum byPseudomonas fluorescens AH2, a Possible Probiotic Treatment of Fish. Applied and Environmental Microbiology. 65. 3. 969–973. EN. 10.1128/AEM.65.3.969-973.1999. 10049849. 91130. 1999ApEnM..65..969G.
  11. Gram. Lone. Christensen. Allan Beck. Ravn. Lars. Molin. Søren. Givskov. Michael. 1999-08-01. Production of Acylated Homoserine Lactones by Psychrotrophic Members of the Enterobacteriaceae Isolated from Foods. Applied and Environmental Microbiology. 65. 8. 3458–3463. EN. 10.1128/AEM.65.8.3458-3463.1999. 10427034. 91519 . 1999ApEnM..65.3458G. 30130863.
  12. Kingshott. Peter. Wei. Jiang. Bagge-Ravn. Dorthe. Gadegaard. Nikolaj. Gram. Lone. 2003-08-01. Covalent Attachment of Poly(ethylene glycol) to Surfaces, Critical for Reducing Bacterial Adhesion. Langmuir. 19. 17. 6912–6921. 10.1021/la034032m. 0743-7463.
  13. Vogel. Birte Fonnesbech. Venkateswaran. Kasthuri. Satomi. Masataka. Gram. Lone. 2005. Identification of Shewanella baltica as the Most Important H2S-Producing Species during Iced Storage of Danish Marine Fish. Applied and Environmental Microbiology. 71. 11. 6689–6697. EN. 10.1128/AEM.71.11.6689-6697.2005. 1287644. 16269698. 2005ApEnM..71.6689V.
  14. Web site: Tachibana. Chris. 2013-05-16. Blue biotechnology wave - Nordic Life Science. 2022-01-15. Nordic Life Science – the leading Nordic life science news service. en-US.
  15. Gram. Lone. Melchiorsen. Jette. Bruhn. Jesper Bartholin. 2010. Antibacterial Activity of Marine Culturable Bacteria Collected from a Global Sampling of Ocean Surface Waters and Surface Swabs of Marine Organisms. Marine Biotechnology. en. 12. 4. 439–451. 10.1007/s10126-009-9233-y. 19823914. 27071269. 1436-2228.
  16. Sonnenschein. Eva C. Nielsen. Kristian F. D'Alvise. Paul. Porsby. Cisse H. Melchiorsen. Jette. Heilmann. Jens. Kalatzis. Panos G. López-Pérez. Mario. Bunk. Boyke. Spröer. Cathrin. Middelboe. Mathias. 2017. Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis. The ISME Journal. en. 11. 2. 569–583. 10.1038/ismej.2016.111. 1751-7362. 5270555. 27552638.
  17. Giubergia. Sonia. Phippen. Christopher. Gotfredsen. Charlotte H.. Nielsen. Kristian Fog. Gram. Lone. 2016-04-29. Influence of Niche-Specific Nutrients on Secondary Metabolism in Vibrionaceae. Applied and Environmental Microbiology. 82. 13. 4035–4044. EN. 10.1128/AEM.00730-16. 4907173. 27129958. 2016ApEnM..82.4035G.
  18. Web site: Bacteria researcher receives annual award of DKK 5 million - DTU. 2022-01-15. www.dtu.dk. en.
  19. Web site: Professor Lone Gran decorated with the Order of Dannebrog - CeMiSt. 2022-01-15. Center for Microbial Secondary Metabolites. en.
  20. Web site: Lone Gram. 2022-01-15. Welcome to DTU Research Database. en.
  21. Web site: Shekhar. Akarsh. 2020-10-22. Hans Christian Gram: 8 Facts About The Man Who Invented the Famous 'Stain Technique'. 2022-01-15. DailyHawker. en-US.
  22. Web site: February 27, 2017. Opening of the Danish National Research Foundation DNRF, Center of Excellence:Center for microbial secondary metabolites (Cemist). Danish National Research Foundation.

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