| Liu Chi-chun | |
| Order1: | 2nd |
| Office1: | First Lady of Taiwan |
| Term Label1: | In role |
| President1: | Yen Chia-kan |
| Term Start1: | 5 April 1975 |
| Term End1: | 20 May 1978 |
| Predecessor1: | Soong May-ling |
| Successor1: | Faina Vakhreva Chiang |
| Office2: | 3rd Second Lady of Taiwan |
| Term Label2: | In role |
| Term Start2: | 20 May 1966 |
| Term End2: | 5 April 1975 |
| Vicepresident2: | Yen Chia-kan |
| Predecessor2: | Tan Xiang |
| Successor2: | Pan Ying-ching |
| Office3: | Spouse of the Prime Minister of Taiwan |
| Term Label3: | In role |
| Term Start3: | 16 December 1963 |
| Term End3: | 1 June 1972 |
| Primeminister3: | Yen Chia-kan |
| Predecessor3: | Tan Xiang |
| Successor3: | Faina Vakhreva Chiang |
| Birth Date: | 1908 |
| Birth Place: | Suzhou, Jiangsu, Qing China |
| Death Place: | Taipei, Taiwan |
| Children: | 9 |
| Nationality: | Taiwanese |
Liu Chi-chun (; 1908–1999) was the First Lady of the Republic of China (Taiwan) from 1975 until 1978 as the wife of Yen Chia-kan, former President of the Republic of China.
Liu Chi-chun was born at Suzhou, and her family was one of the four prominent families in the city. She was the distant cousin of her later husband Yen Chia-kan. Yen's first wife died in 1923 because of obstructed labour. After that, Yen continued to follow the choice of his parents to marry her in December 1924.
She put much effort into looking after her new family, and she had nine children (five sons and four daughters). After she became the first lady, she continued to take care of her child, but not to participate on political topics. After Yen Chia-kan finished his presidency, she disappeared from public view.
After her husband Yen Chia-kan died on December 24, 1993, she died at the same date six years later (in 1999) because of diseases of the lung, liver and kidney at Taipei Chongqing South Road official residence.[1] Her marriage lasted for 70 years. Finally, her remains were interred at the Republic Of China Military Cemetery.