| Little Santa Cruz Island | |
| Map: | Philippines |
| Map Relief: | yes |
| Location: | Basilan Strait |
| Coordinates: | 6.8842°N 122.0425°W |
| Country: | Philippines |
| Country Admin Divisions Title: | Region |
| Country Admin Divisions Title 1: | City |
| Country Admin Divisions 1: | Zamboanga City |
Little Santa Cruz Island is an island situated south of downtown Zamboanga City, on the Basilan Strait.