| Little River | |
| Name Other: | Tributary to Eno River |
| Map Size: | 300 |
| Pushpin Map: | North Carolina#USA |
| Pushpin Map Size: | 300 |
| Pushpin Map Caption: | Location of Little River mouth |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | North Carolina |
| Subdivision Type3: | County |
| Subdivision Name3: | Durham |
| Length: | 12.83miles[1] |
| Discharge1 Location: | Durham, North Carolina |
| Discharge1 Avg: | 107.74cuft/s at mouth with Eno River[2] |
| Source1: | confluence of North and South Forks of Little River |
| Source1 Location: | about 3 miles north of Durham, North Carolina[3] |
| Source1 Coordinates: | 36.1514°N -78.9417°W[4] |
| Source1 Elevation: | 420feet[5] |
| Mouth: | Eno River |
| Mouth Location: | Durham, North Carolina[6] |
| Mouth Coordinates: | 36.0719°N -78.8442°W[7] |
| Mouth Elevation: | 255feet[8] |
| Progression: | Eno River → Neuse River → Pamlico Sound → Atlantic Ocean |
| River System: | Neuse River |
| Basin Size: | [9] |
| Tributaries Left: | North Fork Little River Mountain Creek |
| Tributaries Right: | South Fork Little River Cabin Branch |
| Waterbodies: | Little River Reservoir |
Little River is a 12.83miles long tributary to the Eno River in Durham County, North Carolina. Little River along with the Flat River are the major tributaries to the Eno River before it enters Falls Lake.
Both the North Fork of Little River and the South Fork begin in northern Orange County, North Carolina near Hurdle Mills Road. The South and North Forks come together in a confluence near Guess Road and South Lowell Road in northern Durham County. 5.5 miles southeast of the confluence, the Little River is dammed to form the Little River Reservoir, a drinking water source for the City of Durham. The damming of the river in 1983 flooded a significant portion of the historic community of Orange Factory.[10]